國家衛生研究院 NHRI:Item 3990099045/13129
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 907802      在线人数 : 926
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/13129


    题名: Sub-multiplicative interaction between polygenic risk score and household coal use in relation to lung adenocarcinoma among never-smoking women in Asia
    作者: Blechter, B;Wong, JYY;Agnes Hsiung, C;Hosgood, HD;Yin, Z;Shu, XO;Zhang, H;Shi, J;Song, L;Song, M;Zheng, W;Wang, Z;Caporaso, N;Burdette, L;Yeager, M;Berndt, SI;Teresa Landi, M;Chen, CJ;Chang, GC;Hsiao, CF;Tsai, YH;Chen, KY;Huang, MS;Su, WC;Chen, YM;Chien, LH;Chen, CH;Yang, TY;Wang, CL;Hung, JY;Lin, CC;Perng, RP;Chen, CY;Chen, KC;Li, YJ;Yu, CJ;Chen, YS;Chen, YH;Tsai, FY;Jie Seow, W;Bassig, BA;Hu, W;Ji, BT;Wu, W;Guan, P;He, Q;Gao, YT;Cai, Q;Chow, WH;Xiang, YB;Lin, D;Wu, C;Wu, YL;Shin, MH;Hong, YC;Matsuo, K;Chen, K;Pik Wong, M;Lu, D;Jin, L;Wang, JC;Seow, A;Wu, T;Shen, H;Fraumeni, JF;Yang, PC;Chang, IS;Zhou, B;Chanock, SJ;Rothman, N;Chatterjee, N;Lan, Q
    贡献者: Institute of Population Health Sciences;National Institute of Cancer Research
    摘要: We previously identified 10 lung adenocarcinoma susceptibility loci in a genome-wide association study (GWAS) conducted in the Female Lung Cancer Consortium in Asia (FLCCA), the largest genomic study of lung cancer among never-smoking women to date. Furthermore, household coal use for cooking and heating has been linked to lung cancer in Asia, especially in Xuanwei, China. We investigated the potential interaction between genetic susceptibility and coal use in FLCCA. We analyzed GWAS-data from Taiwan, Shanghai, and Shenyang (1472 cases; 1497 controls), as well as a separate study conducted in Xuanwei (152 cases; 522 controls) for additional analyses. We summarized genetic susceptibility using a polygenic risk score (PRS), which was the weighted sum of the risk-alleles from the 10 previously identified loci. We estimated associations between a PRS, coal use (ever/never), and lung adenocarcinoma with multivariable logistic regression models, and evaluated potential gene-environment interactions using likelihood ratio tests. There was a strong association between continuous PRS and lung adenocarcinoma among never coal users (Odds Ratio (OR) = 1.69 (95% Confidence Interval (CI) = 1.53, 1.87), p=1 × 10(-)(26)). This effect was attenuated among ever coal users (OR = 1.24 (95% CI: 1.03, 1.50), p = 0.02, p-interaction = 6 × 10(-3)). We observed similar attenuation among coal users from Xuanwei. Our study provides evidence that genetic susceptibility to lung adenocarcinoma among never-smoking Asian women is weaker among coal users. These results suggest that lung cancer pathogenesis may differ, at least partially, depending on exposure to coal combustion products. Notably, these novel findings are among the few instances of sub-multiplicative gene-environment interactions in the cancer literature.
    日期: 2020-12-29
    關聯: Environment International. 2020 Dec 29;147:Article number 105975.
    Link to: http://dx.doi.org/10.1016/j.envint.2020.105975
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0160-4120&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000614535400002
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85098869659
    显示于类别:[熊昭] 期刊論文
    [張憶壽] 期刊論文
    [蕭金福] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    PUB33385923.pdf543KbAdobe PDF278检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈