國家衛生研究院 NHRI:Item 3990099045/13311

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Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/13311

Title:	Total synthesis of landomycins Q and R and related core structures for exploration of the cytotoxicity and antibacterial properties
Authors:	Lai, YH;Mondal, S;Su, HT;Huang, SC;Wu, MH;Huang, I;Yang Lauderdale, TL;Song, JS;Shia, KS;Mong, KK
Contributors:	Institute of Biotechnology and Pharmaceutical Research;National Institute of Infectious Diseases and Vaccinology
Abstract:	Herein, we report the total synthesis of landomycins Q and R as well as the aglycone core, namely anhydrolandomycinone and a related core analogue. The synthesis features an acetate-assisted arylation method for construction of the hindered B-ring in the core component and a one-pot aromatization-deiodination-denbenzylation procedure to streamline the global functional and protecting group manuipulation. Subsequent cytotoxicity and antibacterial studies revealed that the landomycin R is a potential antibacterial agent against methicillin-resistantStaphylococcus aureus.
Date:	2021-03-02
Relation:	RSC Advances. 2021 Mar 2;11(16):9426-9432.
Link to:	http://dx.doi.org/10.1039/d1ra01088c
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2046-2069&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000626753100034
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85102321244
Appears in Collections:	[Kak-Shan Shia] Periodical Articles [Tsai-Ling Yang Lauderdale] Periodical Articles

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