國家衛生研究院 NHRI:Item 3990099045/13311
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    題名: Total synthesis of landomycins Q and R and related core structures for exploration of the cytotoxicity and antibacterial properties
    作者: Lai, YH;Mondal, S;Su, HT;Huang, SC;Wu, MH;Huang, I;Yang Lauderdale, TL;Song, JS;Shia, KS;Mong, KK
    貢獻者: Institute of Biotechnology and Pharmaceutical Research;National Institute of Infectious Diseases and Vaccinology
    摘要: Herein, we report the total synthesis of landomycins Q and R as well as the aglycone core, namely anhydrolandomycinone and a related core analogue. The synthesis features an acetate-assisted arylation method for construction of the hindered B-ring in the core component and a one-pot aromatization-deiodination-denbenzylation procedure to streamline the global functional and protecting group manuipulation. Subsequent cytotoxicity and antibacterial studies revealed that the landomycin R is a potential antibacterial agent against methicillin-resistantStaphylococcus aureus.
    日期: 2021-03-02
    關聯: RSC Advances. 2021 Mar 2;11(16):9426-9432.
    Link to: http://dx.doi.org/10.1039/d1ra01088c
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2046-2069&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000626753100034
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85102321244
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