國家衛生研究院 NHRI:Item 3990099045/13312
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    题名: Chlorinated briarane diterpenoids from octocoral Briareum stechei (Kükenthal, 1908)
    作者: Huynh, TH;Lee, GH;Tanaka, J;Hsieh, HP;Kelvin Tsou, L;Zhang, MM;Kuo, TJ;Wen, ZH;Lu, CK;Sung, PJ
    贡献者: Institute of Biotechnology and Pharmaceutical Research;Institute of Molecular and Genomic Medicine
    摘要: Six 6-chlorine-containing briarane analogues, including two new compounds, briarenols U (1) and V (2), as well as four known metabolites, solenolides B (3) and E (4); briaexcavatolide E (5); and brianolide (6) were isolated from an octocoral identified as Briareum stechei. The structures of compounds 1–6 were elucidated by using spectroscopic methods, and the stereochemistry of solenolide B (3) was revised. The absolute configuration of 6 was further determined by a single-crystal X-ray diffraction analysis. Briarane 1 was found to induce significant in vitro inflammatory activity in LPS-induced RAW264.7 macrophage cells by enhancing the expression of iNOS and COX-2 protein.
    日期: 2021-04-13
    關聯: Tetrahedron Letters. 2021 Apr 13;69:Article number 152976.
    Link to: http://dx.doi.org/10.1016/j.tetlet.2021.152976
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0040-4039&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000636319400016
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85102873212
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