國家衛生研究院 NHRI:Item 3990099045/13320

NHRI > National Institute of Cancer Research > Shih-Sheng Jiang > Conference Papers/Meeting Abstract > Item 3990099045/13320

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/13320

Title:	IGFBP3 promotes radiosensitivity of OSCC via appositive feedback of NF kappa B/IL-6/ROS signaling
Other Titles:	IGFBP3 promotes radiosensitivity of OSCC via appositive feedback of NF κ B/IL-6/ROS signaling
Authors:	Wang, SH;Chen, YL;Hsiao, JR;Tsai, FY;Jiang, SS;Lee, AYL;Tsai, HJ;Chen, YW
Contributors:	National Institute of Cancer Research
Abstract:	Insulin-like growth factor binding protein 3 promotes expression previously demonstrated to enhance lymph node metastasis of oral squamous cell carcinoma cells. However, OSCC patients with high IGFBP3 expression had a better prognostic outcome than those with low IGFBP3 expression. We found that ectopic IGFBP3 expression enhanced the ionizing radiation -induced cell-killing effect. In vivo, IGFBP3 reduced tumor growth and increased apoptotic signals in nude mice treated with IR. Combined with IR, ectopic IGFBP3 expression induced mitochondria-dependent cell apoptosis. IGFBP3-induced cell death as evidenced by mitochondria destruction and increase of reactive ROS production. IGFBP3 expression enhanced NK- κ B activation and downstream cytokine expression. IGFBP3-mediated ROS production was reduced by the NK- κ B inhibitor BMS-345541, while exogenous IL-6 rescued the NF- κ B-inhibited, IGFBP3-mediated ROS production. Collectively, our data demonstrated that IGFBP3, a penitential radiosensitive biomarker, promoted OSCC cell death under IR via positive feedback of ROS production by inducing NF- κ B activation and cytokine expression.
Date:	2021-02
Relation:	Cancer Science. 2021 Feb;112(Suppl. 1):776.
Link to:	https://doi.org/10.1111/cas.14823
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1347-9032&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000618060103353
Appears in Collections:	[Shih-Sheng Jiang] Conference Papers/Meeting Abstract [Alan Yueh-Luen Lee] Conference Papers/Meeting Abstract [Ya-Wen Chen] Conference Papers/Meeting Abstract [Hui-Jen Tsai] Conference Papers/Meeting Abstract

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