國家衛生研究院 NHRI:Item 3990099045/13320
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    題名: IGFBP3 promotes radiosensitivity of OSCC via appositive feedback of NF kappa B/IL-6/ROS signaling
    其他題名: IGFBP3 promotes radiosensitivity of OSCC via appositive feedback of NF κ B/IL-6/ROS signaling
    作者: Wang, SH;Chen, YL;Hsiao, JR;Tsai, FY;Jiang, SS;Lee, AYL;Tsai, HJ;Chen, YW
    貢獻者: National Institute of Cancer Research
    摘要: Insulin-like growth factor binding protein 3 promotes expression previously demonstrated to enhance lymph node metastasis of oral squamous cell carcinoma cells. However, OSCC patients with high IGFBP3 expression had a better prognostic outcome than those with low IGFBP3 expression. We found that ectopic IGFBP3 expression enhanced the ionizing radiation -induced cell-killing effect. In vivo, IGFBP3 reduced tumor growth and increased apoptotic signals in nude mice treated with IR. Combined with IR, ectopic IGFBP3 expression induced mitochondria-dependent cell apoptosis. IGFBP3-induced cell death as evidenced by mitochondria destruction and increase of reactive ROS production. IGFBP3 expression enhanced NK- κ B activation and downstream cytokine expression. IGFBP3-mediated ROS production was reduced by the NK- κ B inhibitor BMS-345541, while exogenous IL-6 rescued the NF- κ B-inhibited, IGFBP3-mediated ROS production. Collectively, our data demonstrated that IGFBP3, a penitential radiosensitive biomarker, promoted OSCC cell death under IR via positive feedback of ROS production by inducing NF- κ B activation and cytokine expression.
    日期: 2021-02
    關聯: Cancer Science. 2021 Feb;112(Suppl. 1):776.
    Link to: https://doi.org/10.1111/cas.14823
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1347-9032&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000618060103353
    顯示於類別:[江士昇] 會議論文/會議摘要
    [李岳倫] 會議論文/會議摘要
    [陳雅雯] 會議論文/會議摘要
    [蔡慧珍] 會議論文/會議摘要

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