INTRODUCTION: The characteristics in dialyzer is associated with mortality in patients with end-stage renal disease (ESRD) receiving hemodialysis (HD). This study is to investigate the effects of dialyzer membranes on 3-year mortality in ESRD patients. METHODS: From the long-term nationwide population database database. Prevalent HD patient during 2005-2012 were enrolled. Our main analysis to calculate the effect was cox regression multivariate model. RESULTS: Overall, the mean age of all population (N=73,565) was 61.0 ± 13.6 years, observation period is 2.46 years ± 0.98 within 3 years and 64.6% used polysulfone (PS), polymethyl methacrylate (PMMA) (11.6%), polyethersulfone (11.4%), and cellulose triacetate (CTA) (10.7%), EVAL (Hazard ratio [HR] 2.72, 95% confidence interval [CI] 1.71-4.33) and CTA (HR 1.35, 95% CI 1.12-1.64) were associated with higher mortality than PS, but PMMA was not. CONCLUSION: EVAL and CTA adversely affected mortality and PMMA had no protective role. Further investigations on membrane characters on HD patients are warranted. Taipei Medical University (TMU) (TMU-JIRB (No. N201804051).
Date:
2022-02
Relation:
Therapeutic Apheresis and Dialysis. 2022 Feb;26(1):55-63.
