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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/1396
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| Title: | Isolation of multipotent cells from human term placenta |
| Authors: | Yen, BL;Huang, HI;Chien, CC;Jui, HY;Ko, BS;Yao, M;Shun, CT;Yen, ML;Lee, MC;Chen, YC |
| Contributors: | Stem Cell Research Center |
| Abstract: | Current sources of stem cells include embryonic stem cells (ESCs) and adult stem cells (ASCs). However, concerns exist with either source: ESCs, with their significant ethical considerations, tumorigenicity, and paucity of cell lines; and ASCs, which are possibly more limited in potential. Thus, the search continues for an ethically conducive, easily accessible, and high-yielding source of stem cells. We have isolated a population of multipotent cells from the human term placenta, a temporary organ with fetal contributions that is discarded postpartum. These placenta-derived multipotent cells (PDMCs) exhibit many markers common to mesenchymal stem cells-including CD105/endoglin/SH-2, SH-3, and SH-4-and they lack hematopoietic-, endothelial-, and trophoblastic-specific cell markers. In addition, PDMCs exhibit ESC surface markers of SSEA-4, TRA-1-61, and TRA-1-80. Adipogenic, osteogenic, and neurogenic differentiation were achieved after culturing under the appropriate conditions. PDMCs could provide an ethically uncontroversial and easily accessible source of multipotent cells for future experimental and clinical applications. |
| Keywords: | Biotechnology & Applied Microbiology;Oncology;Cell Biology;Hematology |
| Date: | 2005-01 |
| Relation: | Stem Cells. 2005 Jan;23(1):3-9. |
| Link to: | http://dx.doi.org/10.1634/stemcells.2004-0098 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1066-5099&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000226259400001 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=19944426620 |
| Appears in Collections: | [陳耀昌(2002-2004)] 期刊論文
[顏伶汝] 期刊論文
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Size | Format | |
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| 000226259400001.pdf | | 499Kb | Adobe PDF | 1713 | View/Open |
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