Loading...
|
Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/1433
|
| Title: | A single nucleotide polymorphism fine mapping study of chromosome 1q42.1 reveals the vulnerability genes for schizophrenia, GNPAT and DISC1: Association with impairment of sustained attention |
| Authors: | Liu, YL;Fann, CSJ;Liu, CM;Chen, WJ;Wu, JY;Hung, SL;Chen, CH;Jou, YS;Liu, SK;Hwang, TJ;Hsieh, MH;Ouyang, WC;Chan, HY;Chen, JJ;Yang, WC;Lin, CY;Lee, SFC;Hwu, HG |
| Contributors: | Division of Mental Health and Substance Abuse Research |
| Abstract: | Background: The marker D1S251 of chromosome 1q42.1 showed significant association with schizophrenia in a Taiwanese sample. We used single nucleotide polymorphism (SNP) fine mapping to search for the vulnerability genes of schizophrenia. Methods: We selected 120 SNPs covering 1 Mb around D1S251 from the public database. These selected SNPs were initially validated if allele frequency was > 10%. Forty-seven validated SNPs were genotyped in 102 families with at least 2 siblings affected with schizophrenia. Results: Two SNP blocks showed significant association with schizophrenia. Block 1 (five-SNP), located between intron 2 and intron 13 of the glyceronephosphate O-acyltransferase (GNPAT) gene, showed the most significant associations using single-locus TDT (z = -2.0 7, p = .038, df = 1) and baplotype association analyses (z = -.1.99, p = .046, df = 1). Block 2 (two-SNP), located between intron 4 and intron 5 of the disrupted-in-schizophrenia 1 (DISC1) gene, also showed the most significant results in both the single-locus ( z = -3.22, p = .0013, df = 1) and haplotype association analyses (z = 3.35, p = .0008, df = 1). The association of the DISC1 gene with schizophrenia was mainly in the patient group with sustained attention deficits as assessed by the Continuous Performance Test. Conclusions: Chromosome 1q42.1 harbors GNPAT and DISC1 as candidate genes for schizophrenia, and DISCI is associated with sustained attention deficits. |
| Keywords: | Neurosciences;Psychiatry |
| Date: | 2006-09-15 |
| Relation: | Biological Psychiatry. 2006 Sep;60(6):554-562. |
| Link to: | http://dx.doi.org/10.1016/j.biopsych.2006.04.024 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0006-3223&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000240840700006 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33748741474 |
| Appears in Collections: | [劉玉麗] 期刊論文
|
Files in This Item:
| File |
Description |
Size | Format | |
|---|
| 000240840700006.pdf | | 280Kb | Adobe PDF | 739 | View/Open |
|
All items in NHRI are protected by copyright, with all rights reserved.
|
