國家衛生研究院 NHRI:Item 3990099045/14708
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    题名: Omicron-specific mRNA vaccine induced cross-protective immunity against ancestral SARS-CoV-2 infection with low neutralizing antibodies
    作者: Shen, KY;Yang, CH;Chen, CT;Ho, HM;Chiu, FF;Huang, CY;Liao, HC;Hsu, CW;Yu, GY;Liao, CL;Chen, HW;Huang, MH;Liu, SJ
    贡献者: National Institute of Infectious Diseases and Vaccinology;Institute of Biotechnology and Pharmaceutical Research
    摘要: The major challenge in COVID-19 vaccine effectiveness is immune escape by SARS-CoV-2 variants. To overcome this, an Omicron-specific mRNA vaccine was designed. The extracellular domain of the spike of the Omicron variant was fused with a modified GCN4 trimerization domain with low immunogenicity (TSomi). After immunization with TSomi mRNA in hamsters, animals were challenged with SARS-CoV-2 virus. The raised nonneutralizing antibodies or cytokine secretion responses can recognize both Wuhan S and Omicron S. However, the raised antibodies neutralized SARS-CoV-2 Omicron virus infection but failed to generate Wuhan virus neutralizing antibodies. Surprisingly, TSomi mRNA immunization protected animals from Wuhan virus challenge. These data indicated that nonneutralizing antibodies or cellular immunity may play a more important role in vaccine-induced protection than previously believed. Next-generation COVID-19 vaccines using the Omicron S antigen may provide sufficient protection against ancestral or current SARS-CoV-2 variants. This article is protected by copyright. All rights reserved.
    日期: 2022-12-02
    關聯: Journal of Medical Virology. 2022 Dec 2;95:Article number e28370.
    Link to: http://dx.doi.org/10.1002/jmv.28370
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0146-6615&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000911465200289
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85145921977
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