國家衛生研究院 NHRI:Item 3990099045/15242
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    题名: Persistence and dynamic structures of diverse cephalosporinase genes in nontyphoidal Salmonella in cross-sectional surveillance in Taiwan
    作者: Lee, YJ;Chang, YC;Lee, IH;Ho, KH;Fang, SB;Lauderdale, TL;Chen, TW;Chen, KC;Huang, CH;Huang, TW
    贡献者: National Institute of Infectious Diseases and Vaccinology
    摘要: Nontyphoidal Salmonella (NTS) is a major foodborne pathogen causing from acute gastroenteritis to bacteremia, particularly in pediatric and elderly patients. Antimicrobial resistance of NTS, especially resistance to extended-spectrum cephalosporins, has emerged over the past decades. Thirteen NTS isolates resistant to ceftriaxone or cefotaxime were collected from a teaching hospital in Taipei, and another three from a tertiary hospital, in New Taipei City, Taiwan, from September 2018 to December 2019. Ten other archived isolates from 2000 to 2017 were also obtained. Serogroup B, C2 and E were significantly associated with ampicillin resistance. Over 90% of these 26 isolates are susceptible to carbapenems and colistin. Genomic epidemiology of these isolates shows that bla(CMY-2)-harboring isolates in different serovars were prevalent over two decades, presumably resulting from highly mobile IncI1 plasmid harboring bla(CMY-2). One type of the IncI1 plasmids contained a mobile element, IS26, which might be involved in acquisition of antimicrobial resistance genes. Two emerging serovars, S. Goldcoast ST358 harboring bla(CTX-M-55) on IncHI2 plasmids and S. Anatum ST64 harboring bla(DHA-1) on IncA/C(2) plasmids persisted in Taiwan possibly through clonal spread. Integration of complete or partial plasmid sequences into host chromosomes or multiplications of the antimicrobial resistance genes also appears to be mediated by IS26, in the two emerging clones. The dynamic movement of cephalosporinase genes mediated by IS26 in NTS is of great concern.
    日期: 2023-08
    關聯: International Journal of Antimicrobial Agents. 2023 Aug;62:Article number 106944.
    Link to: http://dx.doi.org/10.1016/j.ijantimicag.2023.106944
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0924-8579&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001077133700001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85169510627
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