國家衛生研究院 NHRI:Item 3990099045/15242
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 909823      線上人數 : 863
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/15242


    題名: Persistence and dynamic structures of diverse cephalosporinase genes in nontyphoidal Salmonella in cross-sectional surveillance in Taiwan
    作者: Lee, YJ;Chang, YC;Lee, IH;Ho, KH;Fang, SB;Lauderdale, TL;Chen, TW;Chen, KC;Huang, CH;Huang, TW
    貢獻者: National Institute of Infectious Diseases and Vaccinology
    摘要: Nontyphoidal Salmonella (NTS) is a major foodborne pathogen causing from acute gastroenteritis to bacteremia, particularly in pediatric and elderly patients. Antimicrobial resistance of NTS, especially resistance to extended-spectrum cephalosporins, has emerged over the past decades. Thirteen NTS isolates resistant to ceftriaxone or cefotaxime were collected from a teaching hospital in Taipei, and another three from a tertiary hospital, in New Taipei City, Taiwan, from September 2018 to December 2019. Ten other archived isolates from 2000 to 2017 were also obtained. Serogroup B, C2 and E were significantly associated with ampicillin resistance. Over 90% of these 26 isolates are susceptible to carbapenems and colistin. Genomic epidemiology of these isolates shows that bla(CMY-2)-harboring isolates in different serovars were prevalent over two decades, presumably resulting from highly mobile IncI1 plasmid harboring bla(CMY-2). One type of the IncI1 plasmids contained a mobile element, IS26, which might be involved in acquisition of antimicrobial resistance genes. Two emerging serovars, S. Goldcoast ST358 harboring bla(CTX-M-55) on IncHI2 plasmids and S. Anatum ST64 harboring bla(DHA-1) on IncA/C(2) plasmids persisted in Taiwan possibly through clonal spread. Integration of complete or partial plasmid sequences into host chromosomes or multiplications of the antimicrobial resistance genes also appears to be mediated by IS26, in the two emerging clones. The dynamic movement of cephalosporinase genes mediated by IS26 in NTS is of great concern.
    日期: 2023-08
    關聯: International Journal of Antimicrobial Agents. 2023 Aug;62:Article number 106944.
    Link to: http://dx.doi.org/10.1016/j.ijantimicag.2023.106944
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0924-8579&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001077133700001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85169510627
    顯示於類別:[楊采菱] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    PUB37543120.pdf1620KbAdobe PDF111檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋