國家衛生研究院 NHRI:Item 3990099045/15834
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    題名: Downsizing and soft X-ray tomography for cellular uptake of interpenetrated metal-organic frameworks
    作者: Yu, YS;Liang, YY;Hsieh, CC;Lin, ZJ;Cheng, PH;Cheng, CC;Chen, SP;Lai, LJ;Wu, KCW
    貢獻者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Metal-organic frameworks (MOFs) are porous materials with potential in biomedical applications such as sensing, drug delivery, and radiosensitization. However, how to tune the properties of the MOFs for such applications remains challenging. Herein, we synthesized two MOFs, Zr-PEB and Hf-PEB. Zr-PEB can be classified as porous interpenetrated zirconium frameworks (PIZOFs) and Hf-PEB is its analogue. We controlled their sizes while maintaining their crystal structure by employing a coordination modulation strategy. They were designed to serve as sensitizer for X-ray therapy and as potential drug carriers. Comprehensive characterizations of the MOFs' properties have been conducted, and the in vitro biological impacts have been studied. Since viability assay showed that Hf-PEB was more biocompatible compared to Zr-PEB, the cellular uptake of Hf-PEB by cells was evaluated using both fluorescence microscopy and soft X-ray tomography (SXT), and the three-dimensional structure of Hf-PEB in cells was observed. The results revealed the potential of Zr-PEB and Hf-PEB as nanomaterials for biomedical applications and demonstrated that SXT is an effective tool to assist the development of such materials. Synthesis and downsizing of interpenetrated metal-organic frameworks (MOFs) for biomedical applications. Soft X-ray tomography was applied to characterize the cellular uptake of a MOF by cells.
    日期: 2024-05-03
    關聯: Journal of Materials Chemistry B. 2024 May 03;Article in Press.
    Link to: http://dx.doi.org/10.1039/d4tb00329b
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2050-750X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001217612800001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85193072221
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