國家衛生研究院 NHRI:Item 3990099045/15941

NHRI > Institute of Biomedical Engineering and Nanomedicine > Feng-Huei Lin > Periodical Articles > Item 3990099045/15941

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/15941

Title:	Bletilla striata polysaccharide-containing carboxymethyl cellulose bilayer structure membrane for prevention of postoperative adhesion and achilles tendon repair
Authors:	Chen, ZY;Chen, SH;Chen, SH;Chou, PY;Kuan, CY;Yang, IH;Chang, CT;Su, YC;Lin, FH
Contributors:	Institute of Biomedical Engineering and Nanomedicine
Abstract:	Postoperative tissue adhesion and poor tendon healing are major clinical problems associated with tendon surgery. To avoid postoperative adhesion and promote tendon healing, we developed and synthesized a membrane to wrap the surgical site after tendon suturing. The bilayer-structured porous membrane comprised an outer layer [1,4-butanediol diglycidyl ether cross-linked with carboxymethyl cellulose (CX)] and an inner layer [1,4-butanediol diglycidyl ether cross-linked with Bletilla striata polysaccharides and carboxymethyl cellulose (CXB)]. The morphology, chemical functional groups, and membrane structure were determined. In vitro experiments revealed that the CX/CXB membrane demonstrated good biosafety and biodegradability, promoted tenocyte proliferation and migration, and exhibited low cell attachment and anti-inflammatory effects. Furthermore, in in vivo animal study, the CX/CXB membrane effectively reduced postoperative tendon-peripheral tissue adhesion and improved tendon repair, downregulating inflammatory cytokines in the tendon tissue at the surgical site, which ultimately increased tendon strength by 54% after 4 weeks.
Date:	2024-06-27
Relation:	Biomacromolecules. 2024 Jun 27;Article in Press.
Link to:	http://dx.doi.org/10.1021/acs.biomac.4c00463
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1525-7797&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:001258189000001
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85197071246
Appears in Collections:	[Feng-Huei Lin] Periodical Articles

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