國家衛生研究院 NHRI:Item 3990099045/15941
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    题名: Bletilla striata polysaccharide-containing carboxymethyl cellulose bilayer structure membrane for prevention of postoperative adhesion and achilles tendon repair
    作者: Chen, ZY;Chen, SH;Chen, SH;Chou, PY;Kuan, CY;Yang, IH;Chang, CT;Su, YC;Lin, FH
    贡献者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Postoperative tissue adhesion and poor tendon healing are major clinical problems associated with tendon surgery. To avoid postoperative adhesion and promote tendon healing, we developed and synthesized a membrane to wrap the surgical site after tendon suturing. The bilayer-structured porous membrane comprised an outer layer [1,4-butanediol diglycidyl ether cross-linked with carboxymethyl cellulose (CX)] and an inner layer [1,4-butanediol diglycidyl ether cross-linked with Bletilla striata polysaccharides and carboxymethyl cellulose (CXB)]. The morphology, chemical functional groups, and membrane structure were determined. In vitro experiments revealed that the CX/CXB membrane demonstrated good biosafety and biodegradability, promoted tenocyte proliferation and migration, and exhibited low cell attachment and anti-inflammatory effects. Furthermore, in in vivo animal study, the CX/CXB membrane effectively reduced postoperative tendon-peripheral tissue adhesion and improved tendon repair, downregulating inflammatory cytokines in the tendon tissue at the surgical site, which ultimately increased tendon strength by 54% after 4 weeks.
    日期: 2024-06-27
    關聯: Biomacromolecules. 2024 Jun 27;Article in Press.
    Link to: http://dx.doi.org/10.1021/acs.biomac.4c00463
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1525-7797&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001258189000001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85197071246
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