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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/16104
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| Title: | Microvascular disease and its association with dementia in patients with type 2 diabetes: A nationwide cohort study in Taiwan |
| Authors: | Yen, YH;Yen, FS;Ko, FS;Wei, JCC;Huang, YH;Yu, TS;Hwu, CM;Hsu, CC |
| Contributors: | Institute of Population Health Sciences;National Center for Geriatrics and Welfare Research |
| Abstract: | Aim: To assess the likelihood of dementia in individuals with type 2 diabetes (T2D), distinguishing between those with and without microvascular diseases. Methods: Leveraging the National Health Insurance Research Database in Taiwan, we identified individuals newly diagnosed with T2D from 1 January 2009 through 31 December 2014. Multivariable Cox proportional hazard models were used to compare the risk of outcomes. Results: Individuals with microvascular disease had a significantly higher risk of all-cause dementia (adjusted hazard ratio [95% confidence interval] 1.13 [1.09, 1.17]) compared with matched individuals without microvascular disease. In addition, individuals with diabetic kidney disease and diabetic neuropathy were associated with a significantly increased risk of Alzheimer's disease (1.16 [1.02, 1.32] and 1.14 [1.03, 1.27]), vascular dementia (1.21 [1.06, 1.38] and 1.14 [1.02, 1.28]) and other dementia (1.11 [1.04, 1.19] and 1.10 [1.04, 1.16]), respectively, compared with those without microvascular disease. Conclusions: This nationwide cohort study showed that patients with T2D and microvascular disease, particularly diabetic kidney disease and diabetic neuropathy, were associated with a significantly higher risk of Alzheimer's disease, vascular dementia, other dementia and all-cause dementia than those without microvascular disease. |
| Date: | 2024-08-29 |
| Relation: | Diabetes Obesity and Metabolism. 2024 Aug 29;26(11):5399-5407. |
| Link to: | http://dx.doi.org/10.1111/dom.15908 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1462-8902&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:001301188400001 |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85202857271 |
| Appears in Collections: | [許志成] 期刊論文
[許志成] 期刊論文
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| ISI001301188400001.pdf | | 1112Kb | Adobe PDF | 19 | View/Open |
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