國家衛生研究院 NHRI:Item 3990099045/16201
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 12145/12927 (94%)
Visitors : 853345      Online Users : 837
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version


    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/16201


    Title: Salivary antimicrobial peptide in patients with dementia before and after clinical oral rehabilitation programme: A randomised controlled trial
    Authors: Chen, MA;Yang, YH;Liu, CK;Matsuo, K;Hsu, CC;Lin, YC;Huang, HL
    Contributors: Institute of Population Health Sciences;National Center for Geriatrics and Welfare Research
    Abstract: BackgroundEmerging evidence suggests a link between salivary metabolite changes and neurodegenerative dementia, with antimicrobial peptides (AMPs) implicated in its pathogenesis. ObjectiveWe investigated the effects of a clinical oral rehabilitation programme tailored for dementia patients on salivary flow rate, AMP levels and oral health-related quality of life (OHRQoL). MethodsEligible patients were randomly assigned to either the experimental group (EG; n = 28) or the control group (CG; n = 27). Both groups received a leaflet on oral health. In addition, the EG received an oral care intervention that included individual lessons on oral muscle exercises and oral self-care practices. Saliva samples and OHRQoL data were collected at baseline and follow-up visits. Generalised estimating equation models were used to analyse the changes over time. ResultsAt the 3-month follow-up, EG showed significantly lower histatin 5 (HTN-5) levels (beta = -0.08; effect size [ES] = 0.72) than CG. At 6 months, EG exhibited improved salivary flow rate (beta = 0.89; ES = 0.89) and OHRQoL (beta = 6.99; ES = 1.31) compared to CG. Changes in salivary flow rate (beta = 4.03), HTN-5 level (beta = -0.78) and beta-defensin 2 level (BD-2) (beta = -0.91) at 3 months predicted improved OHRQoL at 6 months (all p < 0.05). ConclusionsOur clinical oral rehabilitation programme reduced the level of salivary HTN-5, increased salivary flow rate and enhanced OHRQoL in dementia patients. Furthermore, changes in salivary flow rate, HTN-5 level and BD-2 level were associated with improvements in patients' OHRQoL.
    Date: 2024-10-06
    Relation: Journal of Oral Rehabilitation. 2024 Oct 06;Article in Press.
    Link to: http://dx.doi.org/10.1111/joor.13867
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0305-182X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001329221900001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85205731848
    Appears in Collections:[Chih-Cheng Hsu] Periodical Articles
    [Chih-Cheng Hsu] Periodical Articles

    Files in This Item:

    File Description SizeFormat
    ISI001329221900001.pdf495KbAdobe PDF13View/Open


    All items in NHRI are protected by copyright, with all rights reserved.

    Related Items in TAIR

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback