國家衛生研究院 NHRI:Item 3990099045/16201
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    題名: Salivary antimicrobial peptide in patients with dementia before and after clinical oral rehabilitation programme: A randomised controlled trial
    作者: Chen, MA;Yang, YH;Liu, CK;Matsuo, K;Hsu, CC;Lin, YC;Huang, HL
    貢獻者: Institute of Population Health Sciences;National Center for Geriatrics and Welfare Research
    摘要: BackgroundEmerging evidence suggests a link between salivary metabolite changes and neurodegenerative dementia, with antimicrobial peptides (AMPs) implicated in its pathogenesis. ObjectiveWe investigated the effects of a clinical oral rehabilitation programme tailored for dementia patients on salivary flow rate, AMP levels and oral health-related quality of life (OHRQoL). MethodsEligible patients were randomly assigned to either the experimental group (EG; n = 28) or the control group (CG; n = 27). Both groups received a leaflet on oral health. In addition, the EG received an oral care intervention that included individual lessons on oral muscle exercises and oral self-care practices. Saliva samples and OHRQoL data were collected at baseline and follow-up visits. Generalised estimating equation models were used to analyse the changes over time. ResultsAt the 3-month follow-up, EG showed significantly lower histatin 5 (HTN-5) levels (beta = -0.08; effect size [ES] = 0.72) than CG. At 6 months, EG exhibited improved salivary flow rate (beta = 0.89; ES = 0.89) and OHRQoL (beta = 6.99; ES = 1.31) compared to CG. Changes in salivary flow rate (beta = 4.03), HTN-5 level (beta = -0.78) and beta-defensin 2 level (BD-2) (beta = -0.91) at 3 months predicted improved OHRQoL at 6 months (all p < 0.05). ConclusionsOur clinical oral rehabilitation programme reduced the level of salivary HTN-5, increased salivary flow rate and enhanced OHRQoL in dementia patients. Furthermore, changes in salivary flow rate, HTN-5 level and BD-2 level were associated with improvements in patients' OHRQoL.
    日期: 2024-10-06
    關聯: Journal of Oral Rehabilitation. 2024 Oct 06;Article in Press.
    Link to: http://dx.doi.org/10.1111/joor.13867
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0305-182X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001329221900001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85205731848
    顯示於類別:[許志成] 期刊論文
    [許志成] 期刊論文

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