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http://ir.nhri.org.tw/handle/3990099045/16426
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| Title: | Prognosis of periprosthetic fractures post hip fracture: Unveiling protective role of anti-osteoporotic medication |
| Authors: | F, SH;Kuan, YH;H, CC;Y, RS;L, CY;W, CY |
| Contributors: | National Center for Geriatrics and Welfare Research |
| Abstract: | Objective: Periprosthetic fractures (PPF) near prior hip fracture fixation implants present formidable challenges due to intricate fracture patterns, implant presence, and compromised patient bone quality. Limited research exists on PPF prognosis in osteoporotic hip fracture patients. While anti-osteoporotic medication (AOM) effectively reduces secondary hip fracture risks, its impact on PPFs remains unexplored. Our study aims to address these gaps by assessing the influence of initiating AOM post-hip fracture on PPF occurrence and investigating PPF prognosis in a nationwide cohort of hip fracture patients. Methods: This nationwide cohort study employs Taiwan’s National Health Insurance Research Database (NHIRD) from January 1, 2016, to December 31, 2018, identifying 48,082 hospitalized hip fracture patients with concomitant procedures. Collected demographics include age, gender, comorbidities, and comedications. AOM use within one year post-hip fracture was examined. Primary outcome: periprosthetic fracture risk post-incident hip fracture. Secondary outcomes: subsequent osteoporotic fractures and PPF patient mortality. Fine and Gray’s subdistribution hazard function explored risk factors and AOM effects on PPF. Results: Among 48,082 patients with incident hip fractures, 30,182 (62.7%) were female, mean age 77.9 ± 10.7 y. Over 5 y, 443 (0.92%) developed PPF, with failure probability ranging from 0.58% (first year) to 1.25% (5-y follow-up). AOM users had lower cumulative PPF incidence at 5 y (0.53 vs. 1.08%). AOM post-hip fracture reduced PPF risk by 50% (HR = 0.5, p < 0.0001). Among 443 PPF patients, 22 (4.97%) had subsequent osteoporotic fractures, and 72 (16.25%) died within one year. Conclusion: PPF following an incident hip fracture escalates the risk of imminent fractures and mortality within a year. Employing AOM post-hip fracture may effectively mitigate the risk of PPF. |
| Date: | 2024-08-20 |
| Relation: | Aging Clinical and Experimental Research. 2024 Aug 20;36:S266. |
| Link to: | http://dx.doi.org/10.1007/s40520-024-02766-y |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:001363175502221 |
| Appears in Collections: | [王貞予] 會議論文/會議摘要
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Files in This Item:
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Size | Format | |
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| ISI001363175502221.pdf | | 448Kb | Adobe PDF | 12 | View/Open |
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