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http://ir.nhri.org.tw/handle/3990099045/16902
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| Title: | Brain neuronal integrity in Covid-19 patients in Taiwan |
| Authors: | Liu, TH;Wang, CH;Huang, SF;Tsou, HH;Yu, GY;Chen, ACH;Chen, WJ;Liu, YL |
| Contributors: | Center for Neuropsychiatric Research;Institute of Molecular and Genomic Medicine;Institute of Population Health Sciences;National Institute of Infectious Diseases and Vaccinology |
| Abstract: | Background: COVID-19 has caused a global pandemic characterized by severe pneumonia. Brain structure abnormality has been confirmed in COVID-19 patients in the UK biobank [1]. However, it is not clear whether this abnormality is reversible nor if the abnormality could be detected in the early stage of the disease. Aims & Objectives: In this study, the pathological effect of COVID-19 on the brain integrity was monitored through the utilization of a brain injury bioindicator, neurofilament light chain (NFL) [2]. It can be released from the brain into the peripheral blood when the brain neuronal axon is injured [3]. The study aimed to assess the correlation between the discharge diagnoses and NFL levels in COVID-infected patients. Method: Plasma samples from the National Health Research Institutes (NHRI) Biobank of 400 COVID-19 patients recruited from 24 hospitals across Taiwan were used for NFL analyses by immunoassay. Results: Among the successfully analyzed 394 patients, 10 patients (2.5%) showed an NFL level above 200 pg/ml. The mean NFL levels were significantly higher in patients older than 50 years (P <0.0001). Male patients had a higher NFL level than females (P = 0.008). The increase in plasma levels of NFL was the highest in the first 1-7 days after the COVID-19 diagnosis was confirmed, then gradually decreased within a month. Significant higher NFL levels were observed in patients with hospitalization, respiratory or ICU treatment, and oxygen therapy (P <0.0001). Moreover, higher NFL levels were also correlated with discharge diagnoses of cardiovascular, lung, kidney, and other chronic diseases (P ≦ 0.008). Discussion & Conclusion: COVID-19 infection may cause brain neuronal injury especially in male patients older than 50 years. In addition, the plasma NFL level was associated with a number of clinical features. The results demonstrated that NFL could be an indicator for assessing the brain neuronal integrity following COVID- 19 infection. |
| Date: | 2025-02-12 |
| Relation: | International Journal of Neuropsychopharmacology. 2025 Feb 12;28(Suppl. 1):i130. |
| Link to: | http://dx.doi.org/10.1093/ijnp/pyae059.225 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1461-1457&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:001420043200001 |
| Appears in Collections: | [劉玉麗] 會議論文/會議摘要
[陳為堅] 會議論文/會議摘要
[黃秀芬] 會議論文/會議摘要
[鄒小蕙] 會議論文/會議摘要
[余冠儀] 會議論文/會議摘要
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| ISI001420043200001.pdf | | 1445Kb | Adobe PDF | 29 | View/Open |
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