國家衛生研究院 NHRI:Item 3990099045/16975
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    題名: Mechanism of malignant transformation in arecoline-exposed human oral keratinocytes
    作者: Lai, TY;Ko, YC;Chen, YL;Lin, SF;Chuang, YJ;Shiah, SG
    貢獻者: National Institute of Cancer Research
    摘要: Areca nut chewing is associated with oral potentially malignant disorders (OPMDs), a spectrum of precancerous lesions with variable rates of malignant transformation (1.7–16.9%). This study investigates the molecular alterations underlying this process. Three immortalized oral keratinocyte lines were repeatedly exposed to arecoline, the primary alkaloid in areca nuts, for 5–8months. RNA-seq analysis and functional assays were conducted on vehicle control and arecoline-treated cell pairs. Two of the three cell lines transformed after arecoline exposure, exhibiting anchorage-independent growth in vitro and tumorigenicity in vivo. The upregulated pathways included reactive oxygen species metabolism, cell cycle progression, and regulation of stem cell. Increased expression of stemness-related genes was observed in clinical datasets including oral cancer and OPMDs. This change of gene expression suggests a potential association with epigenetic reprogramming, a recently identified hallmark of cancer. In summary, this study identifies potential molecular targets for intervention and highlights the role of epigenetic alterations in arecoline-induced malignant transformation.
    日期: 2025-01-03
    關聯: Cancer Science. 2025 Jan 03;116(S1):462.
    Link to: http://dx.doi.org/10.1111/cas.16413
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1347-9032&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001401044101122
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