國家衛生研究院 NHRI:Item 3990099045/1717
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1717


    Title: Conditional multipoint linkage analysis using affected sib pairs: An alternative approach
    Authors: Chiu, YF;Liang, KY
    Contributors: Division of Biostatistics and Bioinformatics
    Abstract: Recently, Liang et al. ([2001b] Genet. Epidemiol. 21:105-122) proposed a conditional approach to assess linkage evidence on the target region by incorporating linkage information from an unlinked (reference) region using allele shared 11313 (identity-by-decent) from affected sib pairs. This is carried out by conditioning on the 1131) sharing value at the estimated trait locus of the reference region. Since markers considered are typically non-fully informative, the IBD sharing at each marker needs to be estimated (or imputed). In this report, we propose an alternative approach to deal with the 1131) sharing in the reference region. This new approach makes full use of the observed data without having to categorize the imputed 1131) sharing as needed in Liang et al. ([2001b] Genet. Epidemiol. 21:105-122). We compare these two approaches by simulating data from a variety of two-locus models including heterogeneity, additive and multiplicative with either fully informative markers or non-fully informative markers. The performance of both approaches is quite comparable showing consistent estimates of the trait locus and key genetic parameters.
    Keywords: Genetics & Heredity;Public, Environmental & Occupational Health
    Date: 2004-02
    Relation: Genetic Epidemiology. 2004 Feb;26(2):108-115.
    Link to: http://dx.doi.org/10.1002/gepi.10305
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0741-0395&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000188647800004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0942265596
    Appears in Collections:[Kung-Yee Liang] Periodical Articles
    [Yen-Feng Chiu] Periodical Articles

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