國家衛生研究院 NHRI:Item 3990099045/1717
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    题名: Conditional multipoint linkage analysis using affected sib pairs: An alternative approach
    作者: Chiu, YF;Liang, KY
    贡献者: Division of Biostatistics and Bioinformatics
    摘要: Recently, Liang et al. ([2001b] Genet. Epidemiol. 21:105-122) proposed a conditional approach to assess linkage evidence on the target region by incorporating linkage information from an unlinked (reference) region using allele shared 11313 (identity-by-decent) from affected sib pairs. This is carried out by conditioning on the 1131) sharing value at the estimated trait locus of the reference region. Since markers considered are typically non-fully informative, the IBD sharing at each marker needs to be estimated (or imputed). In this report, we propose an alternative approach to deal with the 1131) sharing in the reference region. This new approach makes full use of the observed data without having to categorize the imputed 1131) sharing as needed in Liang et al. ([2001b] Genet. Epidemiol. 21:105-122). We compare these two approaches by simulating data from a variety of two-locus models including heterogeneity, additive and multiplicative with either fully informative markers or non-fully informative markers. The performance of both approaches is quite comparable showing consistent estimates of the trait locus and key genetic parameters.
    关键词: Genetics & Heredity;Public, Environmental & Occupational Health
    日期: 2004-02
    關聯: Genetic Epidemiology. 2004 Feb;26(2):108-115.
    Link to: http://dx.doi.org/10.1002/gepi.10305
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0741-0395&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000188647800004
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0942265596
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