國家衛生研究院 NHRI:Item 3990099045/1758
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1758


    Title: A unified multipoint linkage analysis of qualitative and quantitative traits for sib-pairs
    Authors: Chang, IS;Chen, MY;Hsiao, CF;Hsiung, CA
    Contributors: Division of Biostatistics and Bioinformatics;National Institute of Cancer Research
    Abstract: By introducing functions of the phenotypes of a sib-pair as weight functions in the study of IBD processes, we present a unified non-parametric approach to linkage analysis of qualitative and quantitative traits in sib-pairs based on IBD data obtained from a set of polymorphic markers. With the introduction of weight functions and an appropriate conditional expectation of IBD processes, these statistical methods should be more efficient in the detection of genetic factors for complex diseases. These methods will be also useful in planning genetic studies. Large sample properties of these methods axe demonstrated.
    Keywords: Statistics & Probability
    Date: 2002-01
    Relation: Statistica Sinica. 2002 Jan;12(1):297-309.
    Link to: http://www3.stat.sinica.edu.tw/statistica/j12n1/j12n115/j12n115.htm
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1017-0405&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000174372800016
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0036376970
    Appears in Collections:[Chao A. Hsiung] Periodical Articles
    [I-Shou Chang] Periodical Articles
    [Chin-Fu Hsiao] Periodical Articles

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