國家衛生研究院 NHRI:Item 3990099045/1979

NHRI > National Institute of Infectious Diseases and Vaccinology > Leung-Kei Siu > Periodical Articles > Item 3990099045/1979

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1979

Title:	A 5-year study of the seroepidemiology of Klebsiella pneumoniae: High prevalence of capsular serotype K1 in Taiwan and implication for vaccine efficacy
Authors:	Fung, CP;Hu, BS;Chang, FY;Lee, SC;Kuo, BIT;Ho, MT;Siu, LK;Liu, CY
Contributors:	Division of Clinical Research
Abstract:	Seroepidemiology of Klebsiella pneumoniae was determined for 1000 nonrepetitive K, pneumoniae isolates collected by a medical center in Taiwan during 1993-1997, Of these, 630 isolates (63%) were from community-acquired infections; the rest were from hospital-acquired infections. The isolates were serotyped according to capsular antigen by countercurrent immunoelectrophoresis. About 77% were typeable. Serotypes K1 and K2 accounted for 21.7% and 9.3% of the isolates, respectively, followed by K57 (5.1%), K54 (4.2%), K21 (3.3%), and K16 (3%), The frequency of serotype K1 among bacteremic isolates (30.8%) far exceeded that reported by other investigators worldwide. Molecular typing of random K1 isolates by pulsed-field gel electrophoresis revealed several different pulsotypes, suggesting a nonclonal spread. This study indicates that a Klebsiella vaccine developed in Europe is not optimal for use in Taiwan because it does not contain the most predominant serotypes-K1, K54, and K57.
Keywords:	Infectious Diseases
Date:	2000-06
Relation:	Journal of Infectious Diseases. 2000 Jun;181(6):2075-2079.
Link to:	http://dx.doi.org/10.1086/315488
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-1899&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000087923900033
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0034100093
Appears in Collections:	[Leung-Kei Siu] Periodical Articles [Monto Ho(1997-2002)] Periodical Articles

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