國家衛生研究院 NHRI:Item 3990099045/2075

NHRI > National Institute of Infectious Diseases and Vaccinology > Ih-Jen Su(2002-2015) > Periodical Articles > Item 3990099045/2075

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2075

Title:	Association of NRAMP 1 gene polymorphism with susceptibility to tuberculosis in Taiwanese aboriginals
Authors:	Hsu, YH;Chen, CW;Sun, HS;Jou, RW;Lee, JJ;Su, IJ
Contributors:	Division of Clinical Research
Abstract:	Background/Purpose: The human homologue of mice natural-resistance-associated macrophage protein I (Nramp 1) gene, NRAMP 1, has been reported to play a role in susceptibility to tuberculosis in humans. The aboriginal population in Taiwan has a five-fold higher prevalence of tuberculosis than people of Han ethnicity. Whether genetic factors such as NRAMP I polymorphism play a role in the prevalence of tuberculosis in Taiwanese aboriginals should be clarified. Methods: NRAMP 1 polymorphism was studied using a case-control design of patients with tuberculosis, including subjects of Han (Hans) and aboriginal ethnicity in Hualien, eastern Taiwan. The polymorphisms of NRAMP 1 at loci INT4, D543N, 77-385C/T, 3-UTR (CAAA) deletion and 5-(CA)n microsatellite markers were assessed by polymerase chain reaction on tissue DNA isolated from 105 aborigines and 110 Hans with tuberculosis. Comparable numbers of ethnically-matched controls were studied simultaneously. Results: Two NRAMP 1 polymorphisms, INT4 and 5-(CA)n, were significantly associated with susceptibility to tuberculosis in aboriginals (p = 0.0070 and p = 0 0031, respectively). However, no association was detected at the five loci of NRAMP 1 polymorphisms among Hans (p > 0.08). Conclusion: Genetic variation in NRAMP 1 may affect susceptibility to and increase risk for tuberculosis in Taiwanese aboriginals. Although environmental factors play an important role in tuberculosis infection, genetic factors such as NRAMP 1 polymorphism may also contribute to the high prevalence of tuberculosis in Taiwanese aboriginals.
Keywords:	Medicine, General & Internal
Date:	2006-05
Relation:	Journal of the Formosan Medical Association. 2006 May;105(5):363-369.
Link to:	https://doi.org/10.1016/S0929-6646(09)60131-5
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0929-6646&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000236861800001
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33645913525
Appears in Collections:	[Ih-Jen Su(2002-2015)] Periodical Articles

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