國家衛生研究院 NHRI:Item 3990099045/2075
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    题名: Association of NRAMP 1 gene polymorphism with susceptibility to tuberculosis in Taiwanese aboriginals
    作者: Hsu, YH;Chen, CW;Sun, HS;Jou, RW;Lee, JJ;Su, IJ
    贡献者: Division of Clinical Research
    摘要: Background/Purpose: The human homologue of mice natural-resistance-associated macrophage protein I (Nramp 1) gene, NRAMP 1, has been reported to play a role in susceptibility to tuberculosis in humans. The aboriginal population in Taiwan has a five-fold higher prevalence of tuberculosis than people of Han ethnicity. Whether genetic factors such as NRAMP I polymorphism play a role in the prevalence of tuberculosis in Taiwanese aboriginals should be clarified. Methods: NRAMP 1 polymorphism was studied using a case-control design of patients with tuberculosis, including subjects of Han (Hans) and aboriginal ethnicity in Hualien, eastern Taiwan. The polymorphisms of NRAMP 1 at loci INT4, D543N, 77-385C/T, 3-UTR (CAAA) deletion and 5-(CA)n microsatellite markers were assessed by polymerase chain reaction on tissue DNA isolated from 105 aborigines and 110 Hans with tuberculosis. Comparable numbers of ethnically-matched controls were studied simultaneously. Results: Two NRAMP 1 polymorphisms, INT4 and 5-(CA)n, were significantly associated with susceptibility to tuberculosis in aboriginals (p = 0.0070 and p = 0 0031, respectively). However, no association was detected at the five loci of NRAMP 1 polymorphisms among Hans (p > 0.08). Conclusion: Genetic variation in NRAMP 1 may affect susceptibility to and increase risk for tuberculosis in Taiwanese aboriginals. Although environmental factors play an important role in tuberculosis infection, genetic factors such as NRAMP 1 polymorphism may also contribute to the high prevalence of tuberculosis in Taiwanese aboriginals.
    关键词: Medicine, General & Internal
    日期: 2006-05
    關聯: Journal of the Formosan Medical Association. 2006 May;105(5):363-369.
    Link to: https://doi.org/10.1016/S0929-6646(09)60131-5
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0929-6646&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000236861800001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33645913525
    显示于类别:[蘇益仁(2002-2015)] 期刊論文

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