國家衛生研究院 NHRI:Item 3990099045/2241
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2241


    Title: Decreased expression of UK114 is related to the differentiation status of human hepatocellular carcinoma
    Authors: Chong, CL;Huang, SF;Hu, CP;Chen, YL;Chou, HY;Chau, GY;Shew, JY;Tsai, YL;Chen, CT;Chang, C;Chen, ML
    Contributors: Division of Molecular and Genomic Medicine;Division of Biotechnology and Pharmaceutical Research
    Abstract: Previous studies have identified that the expression of UK114 is tissue specific and the protein has been found to be most abundant in liver and kidney. However, the expression of UK114 in human hepatocellular carcinoma and its relationship to differentiation and transformation of hepatocellular carcinoma have not been studied. In this study, the expression of UK114 in human hepatocellular carcinoma was examined by Northern and Western blot analyses. We found that UK114 was significantly down-regulated in most of hepatocellular carcinoma tissues compared with adjacent nontumor tissues (72.7%) at both mRNA and protein levels. We looked into the possibility that this decreased expression of UK114 in the hepatocellular carcinoma tissues may play a role in the differentiation or tumorigenicity of hepatocellular carcinoma. Immunohistochemical staining showed that the reduced expression of UK114 in hepatocellular carcinoma tissues was correlated with the tumor differentiation status as graded by the Edmondson-Steiner classification. On the other hand, overexpression of UK114 was not able to suppress the proliferation of human hepatoma cells and tumorigenicity in nude mice. These results suggest that UK114 does not seem to act as a tumor suppressor gene; however, it may useful as a biomarker that will assist in the grading of the differentiation status of hepatocellular carcinoma samples.
    Keywords: Oncology;Public, Environmental & Occupational Health
    Date: 2008-03
    Relation: Cancer Epidemiology Biomarkers and Prevention. 2008 Mar;17(3):535-542.
    Link to: http://dx.doi.org/10.1158/1055-9965.EPI-07-0506
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1055-9965&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000254373600011
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=41549128335
    Appears in Collections:[Shiu-Feng Kathy Huang] Periodical Articles
    [Chiung-Tong Chen] Periodical Articles
    [Chung-Ming Chang] Periodical Articles

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