國家衛生研究院 NHRI:Item 3990099045/2288
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    题名: Detection of SARS-associated coronavirus in throat wash and saliva in early diagnosis
    作者: Wang, WK;Chen, SY;Liu, IJ;Chen, YC;Chen, HL;Yang, CF;Chen, PJ;Yeh, SH;Kao, CL;Huang, LM;Hsueh, PR;Wang, JT;Sheng, WH;Fang, CT;Hung, CC;Hsieh, SM;Su, CP;Chiang, WC;Yang, JY;Lin, JH;Hsieh, SC;Hu, HP;Chiang, YP;Wang, JT;Yang, PC;Chang, SC
    贡献者: Division of Molecular and Genomic Medicine
    摘要: The severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is thought to be transmitted primarily through dispersal of droplets, but little is known about the load of SARS-CoV in oral droplets. We examined oral specimens, including throat wash and saliva, and found large amounts of SARS-CoV RNA in both throat wash (9.58 x 10(2) to 5.93 x 10(6) copies/mL) and saliva (7.08 X 10(3) to 6.38 x 10(8) copies/mL) from all specimens of 17 consecutive probable SARS case-patients, supporting the possibility of transmission through oral droplets. Immunofluorescence study showed replication of SARS-CoV in the cells derived from throat wash, demonstrating the possibility of developing a convenient antigen detection assay. This finding, with the high detection rate a median of 4 days after disease onset and before the development of lung lesions in four patients, suggests that throat wash and saliva should be included in sample collection guidelines for SARS diagnosis.
    关键词: Immunology;Infectious Diseases
    日期: 2004-07
    關聯: Emerging Infectious Diseases. 2004 Jul;10(7):1213-1219.
    Link to: http://www.cdc.gov/ncidod/EID/vol10no7/03-1113.htm
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1080-6040&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000222456800005
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84984539674
    显示于类别:[葉秀慧(2001-2005)] 期刊論文

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