國家衛生研究院 NHRI:Item 3990099045/2431

NHRI > National Institute of Environmental Health Sciences > Kuen-Yuh Wu(2001-2008) > Periodical Articles > Item 3990099045/2431

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/2431

Title:	New cytotoxic cyclic peptides and dianthramide from Dianthus superbus
Authors:	Hsieh, PW;Chang, FR;Wu, CC;Wu, KY;Li, CM;Chen, SL;Wu, YC
Contributors:	Division of Environmental Health and Occupational Medicine
Abstract:	Four new cyclic peptides, dianthins C-F (1-4), and a new dianthramide, 4-methoxydianthramide B (5), were isolated from the MeOH extract of the traditional Chinese medicinal plant Dianthus superbus. The sequences of cyclic peptides 1-4 were elucidated as cyclo(Gly(1)-Pro(2)-Phe(3)-Tyr(4)-Val(5)-Ile(6)-), cyclo(Gly(1)-Ser(2)-Leu(3)-Pro(4)-Pro(5)-Ile(6)- Phe(7)-), cyclo(Gly(1)-Pro(1)-Ile(3)-Ser(4)-Phe(5)-Val(6)-), and cyclo(Gly(1)-Pro(2)-Phe(3)-Val(4)-Phe(5)-) on the basis of ESI tandem mass fragmentation analysis, chemical evidence, and extensive 2D NMR methods. The conformation of compound 1 was established as an alpha-helix by CD analysis. Furthermore, compounds 3 and 5 showed cytotoxicities toward the Hep G2 cancer cell line with IC50 values of 2.37 and 4.08, respectively.
Keywords:	Plant Sciences;Chemistry, Applied;Chemistry, Medicinal;Pharmacology & Pharmacy
Date:	2004-09
Relation:	Journal of Natural Products. 2004 Sep;67(9):1522-1527.
Link to:	http://dx.doi.org/10.1021/np040036v
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0163-3864&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000224187700017
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=4644276576
Appears in Collections:	[Kuen-Yuh Wu(2001-2008)] Periodical Articles

Files in This Item:

File	Description	Size	Format
000224187700017.pdf		103Kb	Adobe PDF	625	View/Open

Loading...