國家衛生研究院 NHRI:Item 3990099045/2431
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    题名: New cytotoxic cyclic peptides and dianthramide from Dianthus superbus
    作者: Hsieh, PW;Chang, FR;Wu, CC;Wu, KY;Li, CM;Chen, SL;Wu, YC
    贡献者: Division of Environmental Health and Occupational Medicine
    摘要: Four new cyclic peptides, dianthins C-F (1-4), and a new dianthramide, 4-methoxydianthramide B (5), were isolated from the MeOH extract of the traditional Chinese medicinal plant Dianthus superbus. The sequences of cyclic peptides 1-4 were elucidated as cyclo(Gly(1)-Pro(2)-Phe(3)-Tyr(4)-Val(5)-Ile(6)-), cyclo(Gly(1)-Ser(2)-Leu(3)-Pro(4)-Pro(5)-Ile(6)- Phe(7)-), cyclo(Gly(1)-Pro(1)-Ile(3)-Ser(4)-Phe(5)-Val(6)-), and cyclo(Gly(1)-Pro(2)-Phe(3)-Val(4)-Phe(5)-) on the basis of ESI tandem mass fragmentation analysis, chemical evidence, and extensive 2D NMR methods. The conformation of compound 1 was established as an alpha-helix by CD analysis. Furthermore, compounds 3 and 5 showed cytotoxicities toward the Hep G2 cancer cell line with IC50 values of 2.37 and 4.08, respectively.
    关键词: Plant Sciences;Chemistry, Applied;Chemistry, Medicinal;Pharmacology & Pharmacy
    日期: 2004-09
    關聯: Journal of Natural Products. 2004 Sep;67(9):1522-1527.
    Link to: http://dx.doi.org/10.1021/np040036v
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0163-3864&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000224187700017
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=4644276576
    显示于类别:[吳焜裕(2001-2008)] 期刊論文

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