國家衛生研究院 NHRI:Item 3990099045/2550
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    題名: Arecoline inhibits the 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cytochrome P450 1A1 activation in human hepatoma cells
    作者: Chang, EE;Miao, ZF;Lee, WJ;Chao, HR;Li, LA;Wang, YF;Ko, YC;Tsai, FY;Yeh, SC;Tsou, TC
    貢獻者: Division of Environmental Health and Occupational Medicine
    摘要: In the present study, we investigated the effect of arecoline, a major areca nut alkaloid, on the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)induced activation of cytochrome P4501A1 (CYP1A1) in a human hepatoma cell line Huh-7. We treated Huh-7 cells with 10 nM TCDD in the presence of different concentrations of arecoline (50-300 mu M). Our results indicated that arecoline attenuated the TCDD-induced CYP1A1 enzyme activation with an inhibitory effect on cell proliferation. By using real-time RT-PCR, we demonstrated that arecoline inhibited the TCDD-induced activations of CYP1A1 and AhR repressor (AhRR) mRNA expression in a similar pattern. Our results revealed that arecoline inhibited AhR mRNA expression with no direct effect on CYP1A1 enzyme activity. Therefore, in our present study, the observed inhibitory effect of arecoline on CYP1A1 activation was not due to the up-regulation of AhRR or direct inhibitory effect on CYP1A1 Taken together, here we have demonstrated that arecoline attenuates the TCDD-induced CYP1A1 activation mainly via down-regulation of AhR expression in human hepatoma cells, suggesting the possible involvement of arecoline in the AhR-mediated metabolism of environmental toxicants in liver. (C) 2006 Elsevier B.V. All rights reserved.
    關鍵詞: Engineering, Environmental;Engineering, Civil;Environmental Sciences
    日期: 2007-07-19
    關聯: Journal of Hazardous Materials. 2007 Jul;146(1-2):356-361.
    Link to: http://dx.doi.org/10.1016/j.jhazmat.2006.12.035
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0304-3894&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000248159700046
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=34250322706
    顯示於類別:[鄒粹軍] 期刊論文
    [李立安] 期刊論文
    [葛應欽(2003-2009)] 期刊論文

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