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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3074


    Title: Secondary metabolites from the stem bark of Litsea akoensis and their cytotoxic activity
    Authors: Chang, SY;Cheng, MJ;Kuo, YH;Lee, SJ;Chang, HS;Chen, IS
    Contributors: Division of Biotechnology and Pharmaceutical Research
    Abstract: Six new butanolides, litseadioxanins A and B (1 and 2, resp.) bearing a 1,2-dioxane moiety, litseatrinolides A and B (3 and 4, resp.), and litseakolides D-1 and D-2 (5 and 6, resp.), were isolated from the stem bark of Litsea akoensis, together with six known compounds. The structures of the new compounds were characterized by in-depth NMR-spectroscopic and mass-spectrometric analyses. Butanolides 1-4, and a mixture of 6 and litsenolide E-2, and litsenolide B-1 were tested against human tumor cells, including MCF-7 (human breast adenocarcinoma), NCI-H460 (non-small-cell lung cancer), and SF-268 (glioblastoma) cell lines. Among the tested compounds, litsenolide B-1 exhibited marginal cytotoxic activity against MCF-7, NCI-H460, and SF-268 cell lines in vitro.
    Keywords: Chemistry, Multidisciplinary
    Date: 2008
    Relation: Helvetica Chimica Acta. 2008;91(6):1156-1165.
    Link to: http://dx.doi.org/10.1002/hlca.200890125
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0018-019X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000257531400021
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=55549092107
    Appears in Collections:[李秀珠] 期刊論文

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