國家衛生研究院 NHRI:Item 3990099045/3083

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Title:	Anti-HSV activity of digitoxin and its possible mechanisms
Authors:	Su, CT;Hsu, JTA;Hsieh, HP;Lin, PH;Chen, TC;Kao, CL;Lee, CN;Chang, SY
Contributors:	Division of Biotechnology and Pharmaceutical Research
Abstract:	Herpes simplex virus type I (HSV-1) can establish latent infection in the nervous system and usually leads to life-threatening diseases in immunocompromised individuals upon reactivation. Treatment with conventional nucleoside analogue such as acyclovir is effective in most cases, but drug-resistance may arise due to prolonged treatment in immunocompromised individuals. In this study, we identified an in-use medication, digitoxin, which actively inhibited HSV-1 replication with a 50% effective concentration (EC50) of 0.05 mu M. The 50% cytotoxicity concentration (CC50) of digitoxin is 10.66 mu M and the derived selective index is 213. Several structural analogues of digitoxin such as digoxin, ouabain octahydrate and G-strophanthin also showed anti-HSV activity. The inhibitory effects of digitoxin are likely to be introduced at the early stage of HSV-1 replication and the virus release stage. The observation that digitoxin can inhibit acyclovir-resistant viruses further implicates that digitoxin represents a novel drug class with distinct antiviral mechanisms from traditional drugs.
Keywords:	Pharmacology & Pharmacy;Virology
Date:	2008-07
Relation:	Antiviral Research. 2008 Jul;79(1):62-70.
Link to:	http://dx.doi.org/10.1016/j.antiviral.2008.01.156
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0166-3542&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000256181400008
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=43049149329
Appears in Collections:	[Hsing-Pang Hsieh] Periodical Articles [John Tsu-An Hsu] Periodical Articles

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