國家衛生研究院 NHRI:Item 3990099045/3299

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Title:	Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents
Authors:	Reddy, GR;Kuo, CC;Tan, UK;Coumar, MS;Chang, CY;Chiang, YK;Lai, MJ;Yeh, JY;Wu, SY;Chang, JY;Liou, JP;Hsieh, HP
Contributors:	Division of Biotechnology and Pharmaceutical Research;National Institute of Cancer Research
Abstract:	A series of aroylnaphthalene derivatives were prepared as bioisosteres of combrestatin A-4 and evaluated for anticancer activity. 2-Amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalene, 9 and 8, respectively, showed strong antiproliferative activity with IC(50) values of 2.1-26.3 nM against a panel of human cancer cell lines including multiple-drug resistant cell line. Compound 9 demonstrated better antiproliferative activity and has a comparable tubulin binding efficacy as that of colchicine.
Date:	2008-12-25
Relation:	Journal of Medicinal Chemistry. 2008 Dec 25;51(24):8163-8167.
Link to:	http://dx.doi.org/10.1021/jm8008635
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-2623&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000261876400053
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=58149096782
Appears in Collections:	[Hsing-Pang Hsieh] Periodical Articles [Su-Ying Wu] Periodical Articles [Jang-Yang Chang] Periodical Articles [Ching-Chuan Kuo] Periodical Articles

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