國家衛生研究院 NHRI:Item 3990099045/3326

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Title:	Pharmaceutical design of antimitotic agents based on combretastatins
Authors:	Hsieh, HP;Liou, JP;Mahindroo, N
Contributors:	Division of Biotechnology and Pharmaceutical Research
Abstract:	The design of novel anticancer agents based on the combretastatins, a group of antimitotic agents isolated from the bark of the South African willow tree Combretum caffrum Kuntz, is of considerable contemporary interest. Combretastatin A-4, the most active compound in the group, due to its unique dual features of antitubulin and antivascular properties, has drawn significant attention of medicinal chemists for the design of analogues as novel antitumor agents. To date, 252 references have been published since 1982 and 187 references have been published since 1998 related to combretastatins research. The 102 references related to chemistry efforts can be classified into three different categories including one-atom, two-atom, and three-atom bridgeheads as linker between two aryl rings of combretastatins. This review will particularly elucidate the rationale and strategic tactics towards the development of novel classes of antimitotic agents, based upon combretastatin A-4 as a promising lead. 穢 2005 Bentham Science Publishers Ltd.
Date:	2005-05
Relation:	Current Pharmaceutical Design. 2005 May;11(13):1655-1677.
Link to:	http://dx.doi.org/10.2174/1381612053764751
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1381-6128&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000228912300004
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=18744379774
Appears in Collections:	[Hsing-Pang Hsieh] Periodical Articles

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