國家衛生研究院 NHRI:Item 3990099045/3344

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Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3344

Title:	Aurintricarboxylic acid inhibits influenza virus neuraminidase
Authors:	Hung, HC;Tseng, CP;Yang, JM;Ju, YW;Tseng, SN;Chen, YF;Chao, YS;Hsieh, HP;Shih, SR;Hsu, JTA
Contributors:	Division of Biotechnology and Pharmaceutical Research
Abstract:	There is a continuing threat that the highly pathogenic avian influenza virus will cause future influenza pandemics. In this study, we screened a library of compounds that are biologically active and structurally diverse for inhibitory activity against influenza neuraminidase (NA). We found that aurintricarboxylic acid (ATA) is a potent inhibitor of NA activity of both group-1 and group-2 influenza viruses with IC50s (effective concentration to inhibit NA activity by 50%) values at low micromolar concentrations. ATA was equally potent in inhibiting the NA activity derived from wild-type NA and its H274Y mutant which renders NA resistance to inhibition by oseltamivir. Although ATA is structurally distinct from sialic acid, molecular modeling experiments suggested that ATA binds to NA at the enzyme's substrate binding site. These results indicate that ATA may be a good starting material for the design of a novel class of NA inhibitors for the treatment influenza viruses. 2008 Elsevier B.V. All rights reserved.
Date:	2009-02
Relation:	Antiviral Research. 2009 Feb;81(2):123-131.
Link to:	http://dx.doi.org/10.1016/j.antiviral.2008.10.006
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0166-3542&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000263189800004
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=58149476178
Appears in Collections:	[John Tsu-An Hsu] Periodical Articles [Hsing-Pang Hsieh] Periodical Articles [Yu-Sheng Chao(2002-2013)] Periodical Articles

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