English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12500/13673 (91%)
造訪人次 : 2476007      線上人數 : 103
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/3878


    題名: Pulmonary changes induced by trans, trans-2, 4-decadienal, a component of cooking oil fume
    作者: Wang, CK;Chang, LW;Chang, H;Yang, CH;Tsai, MH;Tsai, HT;Lin, P
    貢獻者: Division of Environmental Health and Occupational Medicine
    摘要: Cooking oil fume (COF) is known to be associated with respiratory diseases and risk of lung cancer. The involvement of Trans, trans-2,4-decadienal (tt-DDE), a major component in COF, is suspected. Male ICR mice were intratracheally instilled with either 8 or 24 mg.kg(-1) tt-DDE weekly for eight weeks. Total numbers and types of cells in bronchoalveolar lavage fluids (BAL), as well as pathologic changes, and inflammatory gene modulations in the lung tissues were assessed. We demonstrated that the number of alveolar macrophages in the BAL fluids was significantly increased in tt-DDE-exposed animals. Histologically, there was a dose-correlated increase in developments of epithelial hyperplasia and granulomatous nodule at the bronchioloalveolar junctions (BAJ). While both Clara and alveolar type II cells were present in the BAJ lesion, only Clara cells were found to be actively proliferative. On the other hand, only alveolar type II cells were found in the BAJ granulomatous nodules. Furthermore, enhanced accumulation of pSTAT3, a known pro-carcinogenic factor, was also detected in many alveolar type II cells at the BAJ lesions. Since both BAJ hyperplasia and enhanced pSTAT3 accumulation are known risk factors associated with increased lung adenocarcinoma development, these findings suggest that tt-DDE may pose risk in lung carcinogenesis.
    日期: 2010-03
    關聯: European Respiratory Journal. 2010 Mar;35(3):667-675.
    Link to: http://dx.doi.org/10.1183/09031936.00140508
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0903-1936&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000275239000029
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77951147381
    顯示於類別:[林嬪嬪] 期刊論文
    [張惠華(1999-2009)] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    ISI000275239000029.pdf1052KbAdobe PDF769檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋