國家衛生研究院 NHRI:Item 3990099045/3934

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Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/3934

Title:	Abnormal expressions of circadian-clock and circadian clock-controlled genes in the livers and kidneys of long-term, high-fat-diet-treated mice
Authors:	Hsieh, MC;Yang, SC;Tseng, HL;Hwang, LL;Chen, CT;Shieh, KR
Contributors:	Division of Biotechnology and Pharmaceutical Research
Abstract:	Objectives: Physiological and behavioral circadian rhythmicities are exhibited by all mammals and are generated by intracellular levels of circadian oscillators, which are composed of transcriptional/translational feedback loops involving a set of circadian-clock genes, such as Clock, Per1-3, Cry1-2, Bmal1, Dbp, E4BP4 and CK1. These circadian-clock genes play important roles in regulating circadian rhythms and also energy homeostasis and metabolism. Determining whether obesity induced by high-fat diet affected the expressions of circadian-clock genes and their related genes in peripheral tissues, was the main focus of this study. To address this issue, we fed male C57BL/6 mice a high-fat diet for 11 months to induce obesity, hyperglycemic, hypercholesterolemic and hyperinsulinemic symptoms, and used quantitative real-time reverse transcription-PCR to measure gene expression levels.Results: We found that the expressions of circadian-clock genes and circadian clock-controlled genes, including Per1-3, Cry1-2, Bmal1, Dbp, E4BP4, CK1, PEPCK, PDK4 and NHE3, were altered in the livers and/or kidneys.Conclusions: These results indicate that obesity induced by high-fat diet alters the circadian-clock system, and obesity and metabolic syndrome are highly correlated with the expressions of circadian-clock genes and their downstream, circadian clock-controlled genes.
Date:	2010-02
Relation:	International Journal of Obesity. 2010 Feb;34(2):227-239.
Link to:	http://dx.doi.org/10.1038/ijo.2009.228
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0307-0565&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000274508100002
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=76749162708
Appears in Collections:	[Chiung-Tong Chen] Periodical Articles

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