國家衛生研究院 NHRI:Item 3990099045/3971
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    題名: Assessment of gene-covariate interactions by incorporating covariates into association mapping
    作者: Chiu, YF;Kao, HY;Chen, YS;Hsu, FC;Yang, HC
    貢獻者: Division of Biostatistics and Bioinformatics
    摘要: ABSTRACT : The HLA region is considered to be the main genetic risk factor for rheumatoid arthritis. Previous research demonstrated that HLA-DRB1 alleles encoding the shared epitope are specific for disease that is characterized by antibodies to cyclic citrullinated peptides (anti-CCP). In the present study, we incorporated the shared epitope and either anti-CCP antibodies or rheumatoid factor into linkage disequilibrium mapping, to assess the association between the shared epitope or antibodies with the disease gene identified. Incorporating the covariates into the association mapping provides a mechanism 1) to evaluate gene-gene and gene-environment interactions and 2) to dissect the pathways underlying disease induction/progress in quantitative antibodies.
    日期: 2009-12-15
    關聯: BMC Proceedings. 2009 Dec 15;3(Suppl. 7):Article number S85.
    Link to: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795988/?tool=pubmed
    顯示於類別:[邱燕楓] 期刊論文

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