國家衛生研究院 NHRI:Item 3990099045/3989
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/3989


    题名: Association study of the SLC25A12 gene and autism in Han Chinese in Taiwan
    作者: Chien, WH;Wu, YY;Gau, SSF;Huang, YS;Soong, WT;Chiu, YN;Chen, CH
    贡献者: Division of Mental Health and Addiction Medicine
    摘要: Purpose: Autism is a childhood-onset neurodevelopmental disorder with a strong genetic component in its etiology. Several studies reported that the solute carrier family 25 member A12 (SLC25A12) gene was associated with autism. This study aimed to replicate this finding in a Han Chinese sample from Taiwan using a population-based case-control approach. Methods: We genotyped two single nucleotide polymorphisms (SNPs, rs2056202 and rs2292813) of the SLC25A12 gene that were previously reported to be associated with autism in 465 patients (402 males and 63 females) and 450 control subjects (227 males and 223 females) from Taiwan. Differences in the genotype, allele, and haplotype frequencies between the two groups were compared. Results: We found no differences in the allele, genotype, or haplotype frequencies of these two SNPs between patients and controls. Conclusions: Our data do not support that the SLC25A12 gene is associated with autism in our population. The discrepant results of other studies may come from the clinical heterogeneity of patients recruited for studies, or the genetic heterogeneity of autism in different populations.
    日期: 2010-02-01
    關聯: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2010 Feb 1;34(1):189-192.
    Link to: http://dx.doi.org/10.1016/j.pnpbp.2009.11.004
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0278-5846&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000274563400032
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=73849086535
    显示于类别:[陳嘉祥(2009-2013)] 期刊論文

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