國家衛生研究院 NHRI:Item 3990099045/3989
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 913577      線上人數 : 1143
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/3989


    題名: Association study of the SLC25A12 gene and autism in Han Chinese in Taiwan
    作者: Chien, WH;Wu, YY;Gau, SSF;Huang, YS;Soong, WT;Chiu, YN;Chen, CH
    貢獻者: Division of Mental Health and Addiction Medicine
    摘要: Purpose: Autism is a childhood-onset neurodevelopmental disorder with a strong genetic component in its etiology. Several studies reported that the solute carrier family 25 member A12 (SLC25A12) gene was associated with autism. This study aimed to replicate this finding in a Han Chinese sample from Taiwan using a population-based case-control approach. Methods: We genotyped two single nucleotide polymorphisms (SNPs, rs2056202 and rs2292813) of the SLC25A12 gene that were previously reported to be associated with autism in 465 patients (402 males and 63 females) and 450 control subjects (227 males and 223 females) from Taiwan. Differences in the genotype, allele, and haplotype frequencies between the two groups were compared. Results: We found no differences in the allele, genotype, or haplotype frequencies of these two SNPs between patients and controls. Conclusions: Our data do not support that the SLC25A12 gene is associated with autism in our population. The discrepant results of other studies may come from the clinical heterogeneity of patients recruited for studies, or the genetic heterogeneity of autism in different populations.
    日期: 2010-02-01
    關聯: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2010 Feb 1;34(1):189-192.
    Link to: http://dx.doi.org/10.1016/j.pnpbp.2009.11.004
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0278-5846&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000274563400032
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=73849086535
    顯示於類別:[陳嘉祥(2009-2013)] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    SCP73849086535.pdf164KbAdobe PDF791檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋