國家衛生研究院 NHRI:Item 3990099045/4675

NHRI > Institute of Biotechnology and Pharmaceutical Research > Shiow-Ju Lee > Conference Papers/Meeting Abstract > Item 3990099045/4675

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/4675

Title:	Chemical constituents and cytotoxic activity of the root of Antidesma hiiranense
Authors:	Lin, CH;Chang, HS;Lee, SJ;Chen, IS;Tsai, IL
Contributors:	Division of Biotechnology and Pharmaceutical Research
Abstract:	Antidesma hiiranense Hayata (Euphorbiaceae) is an endemic shrub which is distributed in the southern and eastern parts at low altitudes of Taiwan. The methanolic extract of the root of this species showed cytotoxicity on high-throughput screening against MCF-7, NCI-H460 and SF-268 cancer cell lines, and was partitioned into EtOAc and H2O-soluble layers. Furthermore, the EtOAc-soluble layer showed cytotoxicity against MCF-7, NCI-H460 and SF-268 cancer cell lines. Investigation of the active EtOAc-soluble layer led to the isolation of twenty-eight compounds, including three new compounds, barbatumol C (1), barbatumol D (2), antidesnenol (3) and twenty-five known compounds, braylin (4), scopoletin (5), cedrelopsin (6), barbatumol A (7), barbatumol B (8), 3-(1,1-dimethylallyl)scopoletin (9), obtusidin (10), antidesmanin A (11), antidesmanin B (12), antidesmanin C (13), antidesnone (14), antidesnol (15), vanillin (16), vanillic acid (17), 4-hydroxybenzaldehyde (18), syringaldehyde (19), 4-hydroxybenzoic acid (20), squalene (21), betulinic acid (22), syrungaresinol (23), α-tocopherol (24), α-tocopherol quinone (25), a mixture of β-sitosterol (26) and stigmasterol (27), and hyeronine (28). The structures of these isolates were elucidated by spectral analyses. Among these isolates, the two known coumarinolignoids antidesmanins B (12) and antidesmanins C (13), showed cytotoxicity against MCF-7 and SF-268 cancer cell lines.
Date:	2008-07
Relation:	Planta Medica. 2008 Jul;74(9):1076.
Link to:	http://dx.doi.org/10.1055/s-0028-1084496
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0032-0943&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000258261801071
Appears in Collections:	[Shiow-Ju Lee] Conference Papers/Meeting Abstract

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