國家衛生研究院 NHRI:Item 3990099045/4675
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 857815      在线人数 : 833
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/4675


    题名: Chemical constituents and cytotoxic activity of the root of Antidesma hiiranense
    作者: Lin, CH;Chang, HS;Lee, SJ;Chen, IS;Tsai, IL
    贡献者: Division of Biotechnology and Pharmaceutical Research
    摘要: Antidesma hiiranense Hayata (Euphorbiaceae) is an endemic shrub which is distributed in the southern and eastern parts at low altitudes of Taiwan. The methanolic extract of the root of this species showed cytotoxicity on high-throughput screening against MCF-7, NCI-H460 and SF-268 cancer cell lines, and was partitioned into EtOAc and H2O-soluble layers. Furthermore, the EtOAc-soluble layer showed cytotoxicity against MCF-7, NCI-H460 and SF-268 cancer cell lines. Investigation of the active EtOAc-soluble layer led to the isolation of twenty-eight compounds, including three new compounds, barbatumol C (1), barbatumol D (2), antidesnenol (3) and twenty-five known compounds, braylin (4), scopoletin (5), cedrelopsin (6), barbatumol A (7), barbatumol B (8), 3-(1,1-dimethylallyl)scopoletin (9), obtusidin (10), antidesmanin A (11), antidesmanin B (12), antidesmanin C (13), antidesnone (14), antidesnol (15), vanillin (16), vanillic acid (17), 4-hydroxybenzaldehyde (18), syringaldehyde (19), 4-hydroxybenzoic acid (20), squalene (21), betulinic acid (22), syrungaresinol (23), α-tocopherol (24), α-tocopherol quinone (25), a mixture of β-sitosterol (26) and stigmasterol (27), and hyeronine (28). The structures of these isolates were elucidated by spectral analyses. Among these isolates, the two known coumarinolignoids antidesmanins B (12) and antidesmanins C (13), showed cytotoxicity against MCF-7 and SF-268 cancer cell lines.
    日期: 2008-07
    關聯: Planta Medica. 2008 Jul;74(9):1076.
    Link to: http://dx.doi.org/10.1055/s-0028-1084496
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0032-0943&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000258261801071
    显示于类别:[李秀珠] 會議論文/會議摘要

    文件中的档案:

    没有与此文件相关的档案.



    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈