邻近类别 會議論文/會議摘要 [27/39] 專利 [0/32] 类别统计 近3年内发表的文件:8(5.56%) 含全文笔数:143(99.31%) 文件下载次数统计 下载大于0次:143(100.00%) 下载大于100次:141(98.60%) 全文下载总次数:87248(84.49%) 最后更新时间: 2024-12-01 00:21 上传排行 数据加载中..... 下载排行 数据加载中..... 最近上传 Development of a humanized antibody... Reducing brain Abeta burden amelior... Development of furanopyrimidine-bas... Targeting the phosphatidylserine-im... Synthesis and evaluation of small m... Extracellular HSP90alpha induces My... The beneficial effects of combining... Acyl-coenzyme a synthetase long-cha... Colloidal assemblies composed of po... The effects of Abeta1-42 binding to...

跳至: (选择年份) 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1985 1980 1975 1970 1960 1950 (选择月份) January February March April May June July August September October November December 或输入年份:

由新到旧排序 由最旧的开始

显示项目1-50 / 144. (共3页) 1 2 3 > >> 每页显示[10|25|50]项目

日期	题名	關聯
2024-07-04	Development of a humanized antibody targeting extracellular HSP90alpha to suppress endothelial-mesenchymal transition-enhanced tumor growth of pancreatic adenocarcinoma cells	Cells. 2024 Jul 04;13(13):Article number 1146.
2024-04	Reducing brain Abeta burden ameliorates high-fat diet-induced fatty liver disease in APP/PS1 mice	Biomedicine and Pharmacotherapy. 2024 Apr;173:Article number 116404.
2023-02-07	Development of furanopyrimidine-based orally active third-generation EGFR inhibitors for the treatment of non-small cell lung cancer	Journal of Medicinal Chemistry. 2023 Feb 7;66(4):2566-2588.
2022-10-13	Targeting the phosphatidylserine-immune checkpoint with a small-molecule maytansinoid conjugate	Journal of Medicinal Chemistry. 2022 Oct 13;65(19):12802-12824.
2022-06-21	Synthesis and evaluation of small molecule drug conjugates harnessing thioester-linked maytansinoids	Pharmaceutics. 2022 Jun 21;14(7):Article number 1316.
2022-01-18	Acyl-coenzyme a synthetase long-chain family member 4 is involved in viral replication organelle formation and facilitates virus replication via ferroptosis	mBio. 2022 Jan 18;13(1):Article number e0271721.
2022-01-11	Extracellular HSP90alpha induces MyD88-IRAK complex-associated IKKalpha/Beta−NF-KappaB/IRF3 and JAK2/TYK2−STAT-3 signaling in macrophages for tumor-promoting M2-polarization	Cells. 2022 Jan 11;11(2):Article number 229.
2022-01-05	The beneficial effects of combining anti-Abeta antibody NP106 and curcumin analog TML-6 on the treatment of Alzheimer’s disease in APP/PS1 mice	International Journal of Molecular Sciences. 2022 Jan 5;23(1):Article number 556.
2021-07-30	The effects of Abeta1-42 binding to the SARS-CoV-2 spike protein S1 subunit and angiotensin-converting enzyme 2	International Journal of Molecular Sciences. 2021 Jul 30;22(15):Article number 8226.
2021-07-16	Colloidal assemblies composed of polymeric micellar/emulsified systems integrate cancer therapy combining a tumor-associated antigen vaccine and chemotherapeutic regimens	Nanomaterials. 2021 Jul 16;11(7):Article number 1844.
2021-01	Effect of a neuropilin-1-derived virus receptor trap on enterovirus A71 infection in vitro	Antimicrobial Agents and Chemotherapy. 2021 Jan;65(1):Article number e00695-20.
2020-12	Engineering a novel IgG-like bispecific antibody against enterovirus A71	Biochemistry and Biophysics Reports. 2020 Dec;24:Article number 100860.
2020-08-20	Discovery of M protease inhibitors encoded by SARS-CoV-2	Antimicrobial Agents and Chemotherapy. 2020 Aug 20;64(9):e00872-20.
2020-08	Artificial intelligence approach fighting COVID-19 with repurposing drugs	Biomedical Journal. 2020 Aug;43(4):355-362.
2020-08	Repurposing old drugs as antiviral agents for coronaviruses	Biomedical Journal. 2020 Aug;43(4):368-374.
2020-06-02	Zika virus NS3 protease pharmacophore anchor model and drug discovery	Scientific Reports. 2020 Jun 2;10:Article number 8929.
2020-05	Antiviral activity of llama-inspired single domain antibody against Enterovirus A71	Antimicrobial Agents and Chemotherapy. 2020 May;64(5):Article number e01922-19.
2020-05	Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors	Bioorganic Chemistry. 2020 May;98:Article number 103689.
2020-04	BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine	Neuropharmacology. 2020 Apr;166:Article number 107678.
2019-11-27	Discovery of a furanopyrimidine-based epidermal growth factor receptor inhibitor (DBPR112) as a clinical candidate for the treatment of non-small cell lung cancer	Journal of Medicinal Chemistry. 2019 Nov 27;62(22):10108-10123.
2019-07-11	Linker optimization and therapeutic evaluation of phosphatidylserine-targeting zinc dipicolylamine-based drug conjugates	Journal of Medicinal Chemistry. 2019 Jul 11;62(13):6047-6062.
2019-05-28	Identification of novel anti-liver cancer small molecules with better therapeutic index than sorafenib via zebrafish drug screening platform	Cancers. 2019 May 28;11(6):Article number 739.
2019-04-01	A novel, potent, and orally bioavailable thiazole HCV NS5A inhibitor for the treatment of hepatitis C virus	European Journal of Medicinal Chemistry. 2019 Apr 1;167:245-268.
2019-02-20	Convallatoxin enhance the ligand-induced mu-opioid receptor endocytosis and attenuate morphine antinociceptive tolerance in mice	Scientific Reports. 2019 Feb 20;9:Article number 2405.
2018-10	Identification of novel Cdc7 kinase inhibitors as anti-cancer agents that target the interaction with Dbf4 by the fragment complementation and drug repositioning approach	EBioMedicine. 2018 Oct;36:241-251.
2018-08-24	BPR1J373, a novel multitargeted kinase inhibitor, effectively suppresses the growth of gastrointestinal stromal tumor	Cancer Science. 2018 Nov;109(11):3591-3601.
2018-01-23	Identification of danthron as an isoform-specific inhibitor of HEME OXYGENASE-1/cytochrome P450 reductase interaction with anti-tumor activity	Journal of Biomedical Science. 2018 Jan 23;25:Article number 6.
2017-09-26	Identification of neuraminidase inhibitors against dual H274Y/I222R mutant strains	Scientific Reports. 2017 Sep 26;7:Article number 12336.
2017-07	Targeting tumor associated phosphatidylserine with new zinc dipicolylamine-based drug conjugates	Bioconjugate Chemistry. 2017 Jul;28(7):1878-1892.
2017-01	A potent, selective, and orally bioavailable HCV NS5A inhibitor for treatment of Hepatitis C Virus: (S)-1-((R)-2-(Cyclopropanecarboxamido)-2-phenylacetyl)-N-(4-phenylthiazo l-2-yl)pyrrolidine-2-carboxamide	Journal of Medicinal Chemistry. 2017 Jan;60(1):228-247.
2016-12	Glucocorticoids may compromise the effect of gefitinib in non-small cell lung cancer	Oncotarget. 2016 Dec;7(52):85917-85928.
2016-12	Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation	Oncotarget. 2016 Dec;7(52):86239-86256.
2016-11-29	Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design	European Journal of Medicinal Chemistry. 2016 Nov 29;124:186-199.
2016-10	BPR1J373, an oral multiple tyrosine kinase inhibitor, targets c-KIT for the treatment of c-KIT driven myeloid leukemia	Molecular Cancer Therapeutics. 2016 Oct;15(10):2323-2333.
2016-09	Mycotoxin patulin suppresses innate immune responses by mitochondrial dysfunction and p62/sequestosome-1-dependent mitophagy	Journal of Biological Chemistry. 2016 Sep;291(37):19299-19311.
2016-07-28	Design and synthesis of 1,2,3-triazole-containing N-acyl zanamivir analogs as potent neuraminidase inhibitors	European Journal of Medicinal Chemistry. 2016 Jul 28;123:397-406.
2016-05-19	Non-small-cell lung cancer cells combat epidermal growth factor receptor tyrosine kinase inhibition through immediate adhesion-related responses	OncoTargets and Therapy. 2016 May 19;9:2961-2973.
2016-02-26	Using mutagenesis to explore conserved residues in the RNA-binding groove of influenza A virus nucleoprotein for antiviral drug development	Scientific Reports. 2016 Feb 26;6:Article number 21662.
2016-01-01	Bispecific antibody conjugated manganese-based magnetic engineered iron oxide for imaging of HER2/neu- and EGFR-expressing tumors	Theranostics. 2016 Jan 1;6(1):118-130.
2015-10	Identification of substituted naphthotriazolediones as novel tryptophan 2,3-dioxygenase (TDO) inhibitors through structure-based virtual screening	Journal of Medicinal Chemistry. 2015 Oct;58 (19):7807-7819.
2015-07	Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations	European Journal of Medicinal Chemistry. 2015 Jul;100:151-161.
2015-06-29	Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification	Scientific Reports. 2015 Jun 29;5:Article number 11702.
2015-06-16	Anchor-based classification and type-C inhibitors for tyrosine kinases	Scientific Reports. 2015 Jun 16;5:Article number 10938.
2015-01-02	KUD773, a phenylthiazole derivative, displays anticancer activity in human hormone-refractory prostate cancers through inhibition of tubulin polymerization and anti-Aurora A activity	Journal of Biomedical Science. 2015 Jan 2;22:Article number 2.
2015-01	Identification of ligand efficient, fragment-like hits from an HTS library: Structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity	Journal of Computer-Aided Molecular Design. 2015 Jan;29(1):89-100.
2014-12	BPR-3P0128 inhibits RNA-dependent RNA polymerase elongation and VPg uridylylation activities of Enterovirus 71	Antiviral Research. 2014 Dec;112:18-25.
2014-11-20	The combination effects of LiCl and the active leflunomide metabolite, A771726, on viral-induced interleukin 6 production and EV-A71 replication	PLoS ONE. 2014 Nov 20;9(11):Article number e111331.
2014-11	Reticulon 3 interacts with NS4B of the hepatitis C virus and negatively regulates viral replication by disrupting NS4B self-interaction	Cellular Microbiology. 2014 Nov;16(11):1603-1618.
2014-08	Ligand efficiency based approach for efficient virtual screening of compound libraries	European Journal of Medicinal Chemistry. 2014 Aug;83:226-235.
2014-05	Facile identification of dual FLT3-Aurora A inhibitors: A computer-guided drug design approach	ChemMedChem. 2014 May;9(5):953-961.

显示项目1-50 / 144. (共3页) 1 2 3 > >> 每页显示[10|25|50]项目