國家衛生研究院 NHRI:Item 3990099045/5390
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/5390


    Title: CyclinD1 protein expressed in pterygia is associated with beta-catenin protein localization
    Other Titles: CyclinD1 protein expressed in pterygia is associated with β-catenin protein localization
    Authors: Tung, JN;Chiang, CC;Tsai, YY;Chou, YY;Yeh, KT;Lee, H;Cheng, YW
    Contributors: Division of Environmental Health and Occupational Medicine
    Abstract: Background: The Wnt (Wg/Wnt) signaling cascade plays an important role in tumorigenesis. Our previous report indicated that aberrant localization of beta-catenin proteins was a feature of pterygia. Therefore, this study aimed to analyze the association of beta-catenin protein and expression of a downstream gene, cyclin D1, in pterygial tissues. Methods: Using immunohistochemistry, beta-catenin and cyclin D1 protein expression was studied, in 150 pterygial specimens and 30 normal conjunctivas. Results: Seventy-three (48.7%) and 60 (40.0%) pterygial specimens tested positive for beta-catenin and cyclin D1 protein expression, respectively. Cyclin D1protein expression was significantly higher in beta-catenin-nuclear/cytoplasmic positive groups than in beta-catenin membrane positive and negative groups (p<0.0001). In addition, cyclin D1 expression was significantly higher in the fleshy group than in the atrophic and intermediate groups (p=0.006). Conclusions: Our study demonstrated that beta-catenin expressed in nuclei/cytoplasm increases cyclinD1 protein expression, which invokes pterygial cell proliferation.
    Date: 2010-12
    Relation: Molecular Vision. 2010 Dec;16(291-97):2733-2738.
    Link to: http://www.molvis.org/molvis/v16/a292/
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1090-0535&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000285507400002
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=78650793113
    Appears in Collections:[Huei Lee(2009-2011)] Periodical Articles

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