國家衛生研究院 NHRI:Item 3990099045/5390
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 856898      線上人數 : 954
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/5390


    題名: CyclinD1 protein expressed in pterygia is associated with beta-catenin protein localization
    其他題名: CyclinD1 protein expressed in pterygia is associated with β-catenin protein localization
    作者: Tung, JN;Chiang, CC;Tsai, YY;Chou, YY;Yeh, KT;Lee, H;Cheng, YW
    貢獻者: Division of Environmental Health and Occupational Medicine
    摘要: Background: The Wnt (Wg/Wnt) signaling cascade plays an important role in tumorigenesis. Our previous report indicated that aberrant localization of beta-catenin proteins was a feature of pterygia. Therefore, this study aimed to analyze the association of beta-catenin protein and expression of a downstream gene, cyclin D1, in pterygial tissues. Methods: Using immunohistochemistry, beta-catenin and cyclin D1 protein expression was studied, in 150 pterygial specimens and 30 normal conjunctivas. Results: Seventy-three (48.7%) and 60 (40.0%) pterygial specimens tested positive for beta-catenin and cyclin D1 protein expression, respectively. Cyclin D1protein expression was significantly higher in beta-catenin-nuclear/cytoplasmic positive groups than in beta-catenin membrane positive and negative groups (p<0.0001). In addition, cyclin D1 expression was significantly higher in the fleshy group than in the atrophic and intermediate groups (p=0.006). Conclusions: Our study demonstrated that beta-catenin expressed in nuclei/cytoplasm increases cyclinD1 protein expression, which invokes pterygial cell proliferation.
    日期: 2010-12
    關聯: Molecular Vision. 2010 Dec;16(291-97):2733-2738.
    Link to: http://www.molvis.org/molvis/v16/a292/
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1090-0535&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000285507400002
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=78650793113
    顯示於類別:[李輝(2009-2011)] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    ISI000285507400002.pdf2655KbAdobe PDF699檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋