國家衛生研究院 NHRI:Item 3990099045/5592
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    题名: Development of sodium-dependent glucose co-transporter 2 inhibitors as potential anti-diabetic therapeutics
    作者: Ho, LT;Kulkarni, SS;Lee, JC
    贡献者: Institute of Biotechnology and Pharmaceutical Research
    摘要: The kidney plays an important role in the regulation of plasma glucose. It is estimated that greater than 99% of the renal glucose filtered by kidney glomerulus is resorbed by sodium-dependent glucose co-transporters (SGLTs), and that SGLT2 located in the proximal renal tubule achieves the most of this assignment. Studies of SGLT2 inhibitors indicate that raising renal glucose excretion by inhibiting SGLT2 helps effectively normalize the plasma glucose levels in individuals with type 2 diabetes mellitus (T2DM). This review discusses the discovery of SGLT2 inhibitors and the related structure-activity relationship (SAR) studies. The clinical trial data of dapagliflozin is also involved.
    日期: 2011-06
    關聯: Current Topics In Medicinal Chemistry. 2011 Jun;11(12):1476-1512.
    Link to: http://dx.doi.org/10.2174/156802611795860915
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1568-0266&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000291636800006
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79959969142
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