國家衛生研究院 NHRI:Item 3990099045/5596

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Title:	Synthesis of 3,3-dimethylglutamic acid derivatives as DPP-IV inhibitors and evaluation of their chemical stability
Authors:	Hsu, T;Tsai, TY;Tseng, YJ;Chiou, MC;Lu, CT;Chao, YS;Jiaang, WT
Contributors:	Institute of Biotechnology and Pharmaceutical Research
Abstract:	A novel five-step synthesis of Boc-3,3-dimethylglutamic acid a-ethyl ester 11 is reported. All the steps are high yielding and simple to carry out. By use of the 3,3-dimethylglutamic acid building block, we successfully discovered a novel class of DPP-IV inhibitors, Glu-Pro-Nitrile dipeptide mimics 2, with high potency (IC50 < 40 nM). The consequence of 3,3-dimethyl substituent on the rate of intramolecular cyclization between N-terminal amine and 5-position amide bond in different buffer solutions was also evaluated.
Date:	2011-02
Relation:	Journal of the Chinese Chemical Society. 2011 Feb;58(1):108-117.
Link to:	http://chemistry.org.tw/public_jour_elec.php?volume=&pageno=&qstring=&flag=&isget=T&page=2
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0009-4536&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000288837600017
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79955525989
Appears in Collections:	[Weir-Torn Jiaang] Periodical Articles [Yu-Sheng Chao(2002-2013)] Periodical Articles [John Tsu-An Hsu] Periodical Articles

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