國家衛生研究院 NHRI:Item 3990099045/5649

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Title:	Toxicological analysis to determine the TDI of melamine in food
Authors:	Hsieh, DPH;Chiang, CF;Chiang, PH;Wen, CP
Contributors:	Division of Health Services and Preventive Medicine
Abstract:	Abstract: Intensified food safety concern over melamine has prompted national authorities to assess its tolerable daily intake (TDI) for protection of general population including young children. TDI is calculated by dividing a no-observed-adverse-effect level (NOAEL) by a safety factor (SF). Based on appropriate choices of values, the U.S. Food and Drug Administration determined two TDI values in the unit of mg per kg body weight per day as first 0.63 and then 0.063, while the World Health Organization, 0.5 and then 0.2, as a result of increasing the SF values in calculation. We used the benchmark dose analysis method on the same set of toxicity data to determine an appropriate NOAEL, and then used an SF of 1000 to obtain a TDI of 0.0081. Arguments in support of this considerably lower TDI value were provided to alert the international community
Date:	2009-12
Relation:	Society For Risk Analysis Annual Meeting 2009. 2009 December 6-9:82.
Link to:	http://birenheide.com/sra/2009AM/program/singlesession.php3?sessid=P&order=82#82
Appears in Collections:	[Po-Huang Chiang] Conference Papers/Meeting Abstract [Chi-Pang Wen(2001-2010)] Conference Papers/Meeting Abstract

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